Serum Levels of IL-6 Type Cytokines and Soluble IL-6 Receptors in Active B-Cell Chronic Lymphocytic Leukemia and in Cladribine Induced Remission [PDF]
Mediators of Inflammation, 1999 We have investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family cytokines-oncostatin M (OSM) and leukemia inhibitory factor (LIF)-in 63 patients with B-cell chronic lymphocytic leukemia (B-CLL) and 17 healthy controls using the ...
T. Robak +4 more
doaj +3 more sources
Frontiers in Immunology, 2019 Background and Purpose: The gp130 family of cytokines signals through receptors dimerizing with the gp130 subunit. Downstream signaling typically activates STAT3 but also SHP2/Ras/MAPK pathways.
Emma Persson +7 more
doaj +3 more sources
Dual Oncostatin M (OSM) Receptors
Journal of Biological Chemistry, 1996 Oncostatin M (OSM) is a cytokine whose structural and functional features are similar to other members of the interleukin (IL)-6 family of cytokines (IL-6, IL-11, leukemia inhibitory factor (LIF), granulocyte colonystimulating factor, ciliary ...
L S Park, David Cosman, B Mosley
exaly +2 more sources
Spatial Organization of Osteoclastic Coupling Factors and Their Receptors at Human Bone Remodeling Sites [PDF]
Frontiers in Molecular Biosciences, 2022 The strictly regulated bone remodeling process ensures that osteoblastic bone formation is coupled to osteoclastic bone resorption. This coupling is regulated by a panel of coupling factors, including clastokines promoting the recruitment, expansion, and
Xenia G. Borggaard +10 more
doaj +2 more sources
Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR. [PDF]
J Biol ChemCiliary neurotrophic factor (CNTF) activates cells via the non-signaling α-receptor CNTF receptor (CNTFR) and the two signaling β-receptors glycoprotein 130 (gp130) and leukemia inhibitory factor receptor (LIFR).
Rafii P +11 more
europepmc +2 more sources
Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair [PDF]
European Cells & Materials, 2013 Mediators in the synovial fluid are thought to play a major role in osteoarthritic cartilage turnover. The purpose of the current study was to investigate the role of oncostatin M (OSM) in osteoarthritis (OA) by evaluating the presence of the cytokine ...
M Beekhuizen +6 more
doaj +2 more sources
Cells, 2022 Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Of the four molecular subgroups, Group 3 MB is the most aggressive and has the worst prognosis.
Lakshana Sreenivasan +3 more
doaj +1 more source
The role of glycoprotein 130 family of cytokines in fetal rat lung development. [PDF]
PLoS ONE, 2013 The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and oncostatin M (OSM ...
Cristina Nogueira-Silva +5 more
doaj +1 more source
IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment
International Journal of Molecular Sciences, 2022 The IL-6 cytokine family is a group of signaling molecules with wide expression and function across vertebrates. Each member of the family signals by binding to its specific receptor and at least one molecule of gp130, which is the common transmembrane ...
Carla M Felcher +2 more
semanticscholar +1 more source
Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation.
PLoS ONE, 2012 A major therapeutic challenge is how to replace bone once it is lost. Bone loss is a characteristic of chronic inflammatory and degenerative diseases such as rheumatoid arthritis and osteoporosis.
Vicky Nicolaidou +7 more
doaj +1 more source