Results 21 to 30 of about 5,557 (173)

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Developmentally regulated IL6-type cytokines signal to germ cells in the human fetal ovary [PDF]

, 2011
Fetal ovarian development and primordial follicle formation are imperative for adult fertility in the female. Data suggest the interleukin (IL)6-type cytokines, leukaemia inhibitory factor (LIF), IL6, oncostatin M (OSM) and ciliary neurotrophic factor ...
R. A. Anderson, Eddie, Sharon L, A. J. Childs, Childs, A J, Childs, Andrew J, Anderson, Richard A, Eddie, Sharon Lynn, Eddie, S L, Jabbour, Henry N, H. N. Jabbour, S. L. Eddie, Jabbour, H N, Anderson, R A   +12 more
core   +1 more source

Humanized Antibodies Targeting Ectodomains of IL‐6R and GP130 Suppress IL‐6/STAT3 Signalling and Tumour Growth in Breast Cancer Models

Journal of Cellular and Molecular Medicine, Volume 30, Issue 12, June 2026.
ABSTRACT Interleukin‐6 (IL‐6) signalling is a key driver of breast cancer progression, activating pro‐survival, pro‐inflammatory and metastatic programs through its receptors, IL‐6R and GP130. Elevated IL‐6 levels correlate with poor prognosis in breast cancer patients and persistent IL‐6/STAT3 activation promotes tumour proliferation, metastasis ...
Satyajit Dey Pereira, Guruprasad Baipadithaya, Keshava Prasad, Ritam Naha, Lavanya Prakash Acharya, Ganesh Prasad Uppenda Gopalakishna, Ramyaa Periasamy, Arun Chandrashekar, Shama Bhat, Manjunath B. Joshi, Kapaettu Satyamoorthy   +10 more
wiley   +1 more source

Regulation of the type II oncostatin M receptor expression in lung-derived epithelial cells

, 1998
Oncostatin M (OSM) is a potent modulator of human lung-derived epithelial cell function. This cytokine binds two distinct receptor complexes: type I OSM receptor which is also a functional receptor for leukemia inhibitory factor (LIF), and type II OSM ...
Ellen Puré, Cichy, Joanna, Stefan Rose-John, Joanna Cichy, Rose-John, Stefan, Puré, Ellen   +5 more
core   +1 more source

The sensory system acts with a neuromedin U signaling pathway to mediate food type-dependent effects on lifespan [PDF]

, 2010
In order to survive, the animal uses its sensory system to interpret the complexity of its environment. Interestingly, a subset of sensory neurons, which function in taste or olfaction, has been found to influence the lifespan of C.
Adilov, Bakhtiyor
core   +1 more source

Auxeticity‐by‐Assembly: Interlocking Modular Auxetic Metamaterials with Selectively Activatable AgNW–Graphene Oxide‐EGaIn Composite Interconnects for Scalable Freeform Photovoltaic Modules

Advanced Functional Materials, Volume 36, Issue 37, 7 May 2026.
Auxeticity‑by‑Assembly converts freeform photovoltaics from cut‑defined layouts to assembly‑defined systems. Standardized interlocking units generate negative‑Poisson‑ratio, reconfigurable architectures, while hinge regions are wired by selectively activatable AgNW–GO@EGaIn composite interconnects and a folding‑enabled interconnector layer. A decimeter‑
Seok Joon Hwang, Jiwon Ryu, Dae‐Hee Cho, YoungHoi Cho, Yewon Hwang, Haram Lee, Dong Hoe Kim, Byeong‐Kwon Ju, Seok Chung, Deokjae Choi, Gee Yeong Kim, Heesuk Jung, Taehee Kim, Hyeonggeun Yu, Gabseok Seo, Phillip Lee   +15 more
wiley   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, Volume 13, Issue 29, 22 May 2026.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Characterization of a gp130 Signaling Receptor Polymorphism [PDF]

, 2013
We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
core  

Interleukin-6 class cytokines regulate the development of inflammatory CNS lesions

, 2012
Purpose/Objective: The interleukin-6 class cytokines leukemia inhibitory factor (LIF) and oncostatin M (OSM) are upregulated in multiple sclerosis (MS) lesions, but their effects on CNS lesion development are far from understood.
Janssens, Kris, Vanwijmeersch, B., Van den Haute, C., Hendriks, Jerome, Baekelandt, Veerle, de Vries, H., Slaets, H., Stinissen, Piet, Hellings, Niels, Op't Eijnde, Bert   +9 more
core   +1 more source