Results 11 to 20 of about 5,557 (173)

Uncovering the promiscuous activity of IL‐6 proteins: A multi‐dimensional analysis of phylogeny, classification and residue conservation [PDF]

Protein Science, 2022
The IL‐6 family of cytokines, known for their pleiotropic behavior, share binding to the gp130 receptor for signal transduction with the necessity to bind other receptors.
A. D. Costa, R. Franco-Duarte, R. Machado, A. Gomes   +3 more
semanticscholar   +2 more sources

Differential Effects of Calcium Alginate and Carboxymethylcellulose Wound Dressing Extracts on Human Sensory Neuron Regeneration and Secretome. [PDF]

Wound Repair Regen
ABSTRACT The peripheral nervous system is critical for wound healing, with sensory nerves releasing neuropeptides that drive tissue repair. Sensory nerve damage impairs healing and contributes to chronic wounds, as observed in diabetic neuropathy. However, the impact of advanced wound dressings on peripheral nerves remains unexplored.
Serbier M, Carpentier G, Sbeih M, Duciel L, Courtils CD, Desmoulière A, Rovini A.   +6 more
europepmc   +2 more sources

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]

, 2004
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Kopp, F. B., Isele, N. B., Cengic, N., Weber, M. M., Engelhardt, D., Spottl, G., Senaldi, G., Auernhammer, Christoph J., Dorn, F., Vlotides, G.   +9 more
core   +1 more source

The role of cytokines in ovarian cancer drug resistance. [PDF]

Int J Cancer
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Wang L, Zang Y, Dejenie R, Bing J, Dong S, Zhang Y, Zhu Y, Li J.   +7 more
europepmc   +2 more sources

A Mendelian Randomization Study and Experimental Validation Investigating the Potential Relationship Among Interleukin-6 Receptor Subunit Beta, Obesity, and Alzheimer's Disease. [PDF]

Brain Behav
This study employs Mendelian randomization (MR) aimed at systematically evaluating the relationship among interleukin‐6 receptor subunit beta, obesity, and Alzheimer's disease (AD). ABSTRACT Objective This study employs Mendelian randomization (MR) aimed at systematically evaluating the relationship among interleukin‐6 receptor subunit beta, obesity ...
Liu Y, Song N, Wang Q, Cui P, Min D.
europepmc   +2 more sources

LIF signaling regulates outer radial glial to interneuron fate during human cortical development [PDF]

, 2023
Radial glial (RG) development is essential for cerebral cortex growth and organization. In humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons and glia.
Clara Siebert, Matthew L. White, Jayden Ross, Wang, Li, Crouch, Elizabeth, Huang, Eric, Raul Morales, White, Matthew, Aparna Bhaduri, Bhaduri, Aparna, Madeline G. Andrews, Kriegstein, Arnold, Morales, Raul, Mukhtar, Tanzila, Ross, Jayden, Megan Donnay, Eric Huang, Shaohui Wang, Parikshak, Neelroop, Elizabeth E. Crouch, Siebert, Clara, Bi, Qiuli, Gemenes, Kaila, Arnold R. Kriegstein, McKinney, Arpana, Tanzila Mukhtar, Neelroop Parikshak, Li Wang, Panagiotakos, Georgia, Andrews, Madeline, Georgia Panagiotakos, Donnay, Megan, Qiuli Bi, Wang, Shaohui, Gradi Bamfonga, Kaila Gemenes, Bamfonga, Gradi, Arpana Arjun McKinney   +37 more
core   +1 more source

Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF

, 2002
Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
George K. Tofaris, Kristjan R. Jessen, Rhona Mirsky, Jessen, KR, Patterson, PH, Tofaris, GK, Mirsky, R, Paul H. Patterson   +7 more
core   +1 more source

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components

, 1994
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases.
Stahl, Neil, Boulton, Teri G., Ihle, James N., Farruggella, Thomas, Ip, Nancy Y., Witthuhn, Bruce A., Quelle, Frederick W., Yancopoulos, George D., Davis, Sam, Barbieri, Giovanna, Pellegrini, Sandra, Silvennoinen, Olli   +11 more
core   +1 more source

Influence of Subunit Combinations on Signaling by Receptors for Oncostatin M, Leukemia Inhibitory Factor, and Interleukin-6*

Journal of Biological Chemistry, 1997
Oncostatin M (OSM), leukemia inhibitory factor (LIF), and interleukin-6 (IL-6) induce expression of a similar set of acute phase plasma protein genes in hepatic cells.
Karen K. Kuropatwinski, Cyr De Imus, D. Gearing, H. Baumann, B. Mosley   +4 more
semanticscholar   +1 more source

OSM/OSMR and Interleukin 6 Family Cytokines in Physiological and Pathological Condition

, 2022
Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines and can bind two different receptors, Leukemia inhibitory factor receptor (LIFR) and Oncostatin M receptor (OSMR), through a complex containing the common glycoprotein 130 ...
Francesca Lantieri, Lantieri, Francesca, Bachetti, Tiziana, Tiziana Bachetti   +3 more
core   +1 more source