Results 1 to 10 of about 10,508 (152)

Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis [PDF]

Frontiers in Immunology, 2023
Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint damage. A series of cytokines are involved in the development of RA.
Liang Han, Jiahui Yan, Tingting Li, Weiji Lin, Yao Huang, Pan Shen, Xin Ba, Ying Huang, Kai Qin, Yinhong Geng, Huanhuan Wang, Kaifeng Zheng, Yafei Liu, Yu Wang, Zhe Chen, Shenghao Tu   +15 more
doaj   +4 more sources

Oncostatin M Modulation of Lipid Storage [PDF]

Biology, 2015
Oncostatin M (OSM) is a cytokine belonging to the gp130 family, whose members serve pleiotropic functions. However, several actions of OSM are unique from those of other gp130 cytokines, and these actions may have critical roles in inflammatory ...
Carrie M Elks, Jacqueline M Stephens, Elks Carrie M   +2 more
exaly   +5 more sources

Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells [PDF]

Communications Biology
The molecular and functional changes in endothelial cells during disease progression such as cancer have been noted but the mechanism of their activation is still under-studied.
Hieu-Huy Nguyen-Tran, Thi-Ngoc Nguyen, Tien Hsu   +2 more
doaj   +2 more sources

Drug Repurposing to Inhibit Oncostatin M in Crohn’s Disease [PDF]

Molecules
Crohn’s disease is an inflammatory bowel disease (IBD) that currently lacks satisfactory treatment options. Therefore, new targets for new drugs are urgently needed to combat this disease.
Faranak Bahramimehr, Axel Guthart, Stefanie Kurz, Yuanping Hai, Mona Dawood, Rümeysa Yücer, Nasim Shahhamzehei, Ralf Weiskirchen, Wilfried Roth, Wolfgang Stremmel, Gerhard Bringmann, Thomas Efferth   +11 more
doaj   +2 more sources

Role and prognostic value of oncostatin M and its receptor OSMR in acute myeloid leukemia, myeloproliferative neoplasms and non-hematological malignancies [PDF]

Frontiers in Oncology
The oncostatin M receptor (OSMR) has recently emerged as an adverse prognostic factor in acute myeloid leukemia (AML) and several non-hematological malignancies.
Jean-Pierre Lévesque, Kavita Bisht, Kylie A. Alexander, Ingrid G. Winkler   +3 more
doaj   +2 more sources

A bibliometric analysis of trends and hotspots in Oncostatin M [PDF]

Discover Oncology
Background Oncostatin M (OSM) belongs to the interleukin-6 (IL-6) cytokine family, with diverse physiological effects impacting various diseases. Despite substantial research on OSM, a systematic overview of the field’s current landscape and evolving ...
Yixuan Ning, Yanqiu Liu, Qingqing Du
doaj   +2 more sources

Oncostatin M Is Related to Polycystic Ovary Syndrome-Case Control Study [PDF]

Biomedicines
Background: Oncostatin M, a novel adipokine, plays a role in oogenesis, lipogenesis, and inflammation and may contribute to polycystic ovary syndrome pathogenesis and related metabolic problems.
Figen Efe Camili, Merve Akis, Ertan Adali, Adnan Adil Hismiogullari, Mine Islimye Taskin, Gurhan Guney, Selim Afsar   +6 more
doaj   +2 more sources

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Cell Reports, 2019
Summary: Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC).
Deepak Parashar, Anjali Geethadevi, Miriam Ragle Aure   +2 more
exaly   +3 more sources

The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review [PDF]

Open Life Sciences
Retinal diseases, which can lead to significant vision loss, are complex conditions involving various cellular and molecular mechanisms. The interleukin-6 (IL-6) family, particularly Oncostatin M (OSM), has garnered attention for their roles in retinal ...
Mori Tommaso, Nagaraj Nareshkumar Ragavachetty, Surico Pier Luigi, Zhou Wenjing, Parmar Uday Pratap Singh, D’Esposito Fabiana, Gagliano Caterina, Musa Mutali, Zeppieri Marco   +8 more
doaj   +2 more sources

“Comparative study of serum and synovial fluid Oncostatin M level in rheumatoid arthritis and osteoarthritis patients”

Journal of Radiation Research and Applied Sciences, 2022
Background: Rheumatoid arthritis (RA) remains a long-standing inflammatory syndrome where the joint synovial membrane is inflamed, with subsequent joint deformation. Osteoarthritis (OA) is considered to be a progressive destruction of articular cartilage
Iman H. Bassyouni, Dina F. Elessawi, Mohamed S. Tawfik, Neveen M. Nosseir   +3 more
doaj   +1 more source