Results 31 to 40 of about 12,338 (205)

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages

Stem Cell Reports, 2017
Summary: In skeletal muscle, new functions for vessels have recently emerged beyond oxygen and nutrient supply, through the interactions that vascular cells establish with muscle stem cells. Here, we demonstrate in human and mouse that endothelial cells (
Claire Latroche, Michèle Weiss-Gayet, Laurent Muller, Cyril Gitiaux, Pascal Leblanc, Sophie Liot, Sabrina Ben-Larbi, Rana Abou-Khalil, Nicolas Verger, Paul Bardot, Mélanie Magnan, Fabrice Chrétien, Rémi Mounier, Stéphane Germain, Bénédicte Chazaud   +14 more
doaj   +1 more source

Oncostatin M and its role in fibrosis [PDF]

Connective Tissue Research, 2018
Oncostain M, a member of the IL-6 family of cytokines, is produced by immune cells in response to infections and tissue injury. OSM has a broad, often context-dependent effect on various cellular processes including differentiation, hematopoiesis, cell proliferation, and cell survival.
Lukasz, Stawski, Maria, Trojanowska
openaire   +2 more sources

Macrophage-derived factors increase low density lipoprotein uptake and receptor number in cultured human liver cells.

Journal of Lipid Research, 1991
Recent evidence suggests the possibility that macrophages can influence lipoprotein metabolism. Therefore we investigated the ability of cultured macrophages to alter low density lipoprotein (LDL) uptake in a human liver cell line (HepG2).
RI Grove, C Mazzucco, N Allegretto, PA Kiener, G Spitalny, SF Radka, M Shoyab, M Antonaccio, GA Warr   +8 more
doaj   +1 more source

Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair [PDF]

European Cells & Materials, 2013
Mediators in the synovial fluid are thought to play a major role in osteoarthritic cartilage turnover. The purpose of the current study was to investigate the role of oncostatin M (OSM) in osteoarthritis (OA) by evaluating the presence of the cytokine ...
M Beekhuizen, GJVM van Osch, AGJ Bot, MCL Hoekstra, DBF Saris, WJA Dhert, LB Creemers   +6 more
doaj  

SupplementaryMethods.docx from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth

, 2021
SupplementaryMethods.docx from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer ...
Ajay Nair (14942440), Pradeep Chaluvally-Raghavan (14953231), Robert F. Schwabe (14953225), Janet S. Rader (14942458), Zhiqiang An (367403), Yunguang Sun (14953219), Hui Deng (455823), Prachi Gupta (3199809), Sunila Pradeep (14942464), William H. Bradley (14953222), Yongsheng Li (10659806), Michael B. Dwinell (8627076), Wei Xiong (58411), Hallgeir Rui (758737), Zhiqiang Ku (381306), Deepak Parashar (14942431), Ishaque P. Kadamberi (14942446), Donna M. McAllister (14953216), Ningyan Zhang (14953228), Anjali Geethadevi (14942437), Jasmine George (345368)   +20 more
core   +1 more source

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

Nature Communications, 2021
Cancer-associated fibroblasts (CAFs) are a major component of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDA). Here the authors report the importance of macrophage-derived Oncostatin M in reprogramming CAFs to drive a pro-tumorigenic ...
Brian Y. Lee, Elizabeth K. J. Hogg, Christopher R. Below, Alexander Kononov, Adrian Blanco-Gomez, Felix Heider, Jingshu Xu, Colin Hutton, Xiaohong Zhang, Tamara Scheidt, Kenneth Beattie, Angela Lamarca, Mairéad McNamara, Juan W. Valle, Claus Jørgensen   +14 more
doaj   +1 more source

WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M

Journal of Inflammation Research, 2021
Petra Henning,1 Sofia Movérare-Skrtic,1 Anna Westerlund,1 Pedro Paulo Chaves de Souza,2,3 Thais Floriano-Marcelino,3 Karin H Nilsson,1 Maha El Shahawy,1,4 Claes Ohlsson,1 Ulf H Lerner1 1Department of Internal Medicine and Clinical Nutrition, Institute of
Henning P, Movérare-Skrtic S, Westerlund A, Souza PPC, Floriano-Marcelino T, Nilsson KH, El Shahawy M, Ohlsson C, Lerner UH   +8 more
doaj  

Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716

Acta Dermato-Venereologica, 2020
To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716,
Carl D. Richards, Rohan Gandhi, Fernando Botelho, Lilian Ho, John F. Paolini   +4 more
doaj   +1 more source

Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M. [PDF]

Cell Rep Med
The discovery of exercise-regulated circulatory factors has fueled interest in organ crosstalk, especially between skeletal muscle and adipose tissue, and the role in mediating beneficial effects of exercise.
Dollet L, Lundell LS, Chibalin AV, Pendergrast LA, Pillon NJ, Lansbury EL, Elmastas M, Frendo-Cumbo S, Jalkanen J, de Castro Barbosa T, Cervone DT, Caidahl K, Dmytriyeva O, Deshmukh AS, Barrès R, Rydén M, Wallberg-Henriksson H, Zierath JR, Krook A.   +18 more
europepmc   +2 more sources

Signaling network of Oncostatin M pathway [PDF]

Journal of Cell Communication and Signaling, 2012
Oncostatin M (OSM), belonging to the IL-6 family of cytokines (Heinrich et al. 2003), was first reported and purified from U937 monocytic cells (Zarling et al. 1986; Ensoli et al. 1999; Hasegawa et al. 1999). In normal physiological condition, OSM is associated with multiple biological processes and cellular responses including growth, differentiation,
Gourav, Dey, Aneesha, Radhakrishnan, Nazia, Syed, Joji Kurian, Thomas, Arpitha, Nadig, Kotteazeth, Srikumar, Premendu Prakash, Mathur, Akhilesh, Pandey, Sze-Kwan, Lin, Rajesh, Raju, T S Keshava, Prasad   +10 more
openaire   +2 more sources