Results 11 to 20 of about 12,338 (205)

Oncostatin M is a regulator of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast-like cells

Scientific Reports, 2023
Renal phosphate and vitamin D metabolism is under the control of fibroblast growth factor 23 (FGF23), an endocrine and paracrine factor predominantly produced in bone. FGF23 formation is stimulated by active vitamin D, or parathyroid hormone (PTH), which
Sina Münz, Martina Feger, Michael Föller   +2 more
doaj   +2 more sources

Extracellular Matrix and Fibrocyte Accumulation in BALB/c Mouse Lung upon Transient Overexpression of Oncostatin M

Cells, 2019
The accumulation of extracellular matrix in lung diseases involves numerous factors, including cytokines and chemokines that participate in cell activation in lung tissues and the circulation of fibrocytes that contribute to local fibrotic responses. The
Fernando M. Botelho, Rebecca Rodrigues, Jessica Guerette, Steven Wong, Dominik K. Fritz, Carl D. Richards   +5 more
doaj   +2 more sources

Evaluating Serum Calprotectin and Serum Oncostatin M Levels as Diagnostic Markers in Crohn's Disease and Ulcerative Colitis Iraqi Patients. Research

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Introduction: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), presents as chronic gastrointestinal inflammation. Timely diagnosis and effective monitoring are crucial for better outcomes.
Yahya G. Karwi, Inam S. Arif, Shaymaa A. Abdulameer   +2 more
doaj   +3 more sources

Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells [PDF]

Mediators of Inflammation, 2016
IL-33 modulates both innate and adaptive immune responses at tissue sites including lung and may play critical roles in inflammatory lung disease.
Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie, Aatif Qureshi, Fernando Botelho   +7 more
doaj   +2 more sources

Hypoxia-inducible factor 1α is up-regulated by oncostatin M and participates in oncostatin M signaling # [PDF]

Hepatology, 2009
Abstract The interleukin-6–type cytokine oncostatin M (OSM) acts via the Janus kinase/signal transducer and activator of transcription pathway as well as via activation of mitogen-activated protein kinases and is known to critically regulate processes such as liver development and regeneration, hematopoiesis, and angiogenesis ...
VOLLMER, Stefan, Kappler, Valérie, KACZOR, Jakub, Flügel, Daniela, ROLVERING, Catherine, Kato, Nobuyuki, Kietzmann, Thomas, BEHRMANN, Iris, HAAN, Claude   +8 more
openaire   +4 more sources

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

Nature Communications, 2018
The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired ...
Srinath C. Sampath, Srihari C. Sampath, Andrew T. V. Ho, Stéphane Y. Corbel, Joshua D. Millstone, John Lamb, John Walker, Bernd Kinzel, Christian Schmedt, Helen M. Blau   +9 more
doaj   +2 more sources

Elevation of Plasma Oncostatin M in Heart Failure

Future Cardiology, 2017
Oncostatin M (OSM) is an inflammatory cytokine of the gp130 family. OSM could participate in adverse cardiovascular remodeling through regulation of FGF23.OSM levels were determined in 80 heart failure patients with reduced left ventricular ejection fraction (HFrEF).OSM levels are significantly increased in HFrEF patients compared with healthy subjects.
Gruson, Damien, Ferracin, Benjamin, Ahn, Sylvie A., Rousseau, Michel   +3 more
openaire   +4 more sources

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Drug Design, Development and Therapy, 2015
Michael R Preusch,1,2 Nicholas Ieronimakis,1 Errol S Wijelath,3 Sara Cabbage,1 Jerry Ricks,1 Florian Bea,2 Morayma Reyes,1 Joanne van Ryn,4 Michael E Rosenfeld1,5 1Department of Pathology, University of Washington, Seattle, WA, USA; 2Department of ...
Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME   +8 more
doaj   +1 more source

Liver Kinase B1 in CD11c⁺ Cells Inhibits Fibrosis in Chronic Pancreatitis via the Oncostatin M Signaling. [PDF]

Adv Sci (Weinh)
This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Zhang W, Guo S, Zhang Y, Ren H, Lei K, Zhao C, Yu Q, Luo H, Xiao Y, Feng X, Li X.   +10 more
europepmc   +2 more sources

Serum oncostatin M at baseline predicts mucosal healing in Crohn's disease patients treated with infliximab [PDF]

, 2020
Background: Oncostatin M is upregulated in Crohn's disease inflamed intestinal mucosa, and has been suggested as a promising biomarker to predict responsiveness to anti-TNF therapy in patients with inflammatory bowel diseases.
Blandizzi C., Fornili M., Ceccarelli L., Bertani L., Baglietto L., Baiano Svizzero G., Fornai M., Benvenuti L., Marchi S., Mumolo M. G., Antonioli L., de Bortoli N., Bellini M., Costa F., Tapete G.   +14 more
core   +1 more source