Results 21 to 30 of about 20,861 (258)

Oncostatin M promotes lipolysis in white adipocytes

Adipocyte, 2022
Oncostatin M (OSM) is a member of the glycoprotein 130 cytokine family that is involved in chronic inflammation and increased in adipose tissue under obesity and insulin resistance. OSM was shown to inhibit adipogenesis, suppress browning, and contribute
Pim P. van Krieken, Julian Roos, Pamela Fischer-Posovszky, Stephan Wueest, Daniel Konrad   +4 more
doaj   +3 more sources

Thrombocytopoietic properties of oncostatin M [PDF]

Blood, 1995
Oncostatin M (OM) is a 28-kD glycoprotein that exhibits a panoply of biologic effects. Based on histologic observations of increased splenic megakaryocytes in nude mice implanted with an OM-secreting cell line, the thrombocytopoietic properties of OM in mice were investigated in culture and in vivo.
PM Wallace, JF MacMaster, J. A. Rillema, Jiao Peng, SA Burstein, M. Shoyab   +5 more
openalex   +3 more sources

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Cell Reports, 2019
Summary: Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC).
Deepak Parashar, Anjali Geethadevi, Miriam Ragle Aure, Jyotsna Mishra, Jasmine George, Changliang Chen, Manoj K. Mishra, Andliena Tahiri, Wei Zhao, Bindu Nair, Yiling Lu, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Amadou K.S. Camara, Mingyu Liang, Janet S. Rader, Ramani Ramchandran, Ming You, Anil K. Sood, Vessela N. Kristensen, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally-Raghavan   +23 more
doaj   +3 more sources

Oncostatin M mediates cardioprotection via angiogenesis in ischemic heart disease [PDF]

American Heart Journal Plus, 2023
Objective: Oncostatin M (OSM) is an inflammatory cytokine belonging to the interleukin-6 family member, which plays an important role in various cardiovascular diseases.
Shohei Ikeda, Koichi Sato, Morihiko Takeda, Mariko Shinozaki, Keita Miki, Michinori Hirano, Koji Fukuda, Nobuyuki Shiba   +7 more
doaj   +2 more sources

Oncostatin M Promotes Mammary Tumor Metastasis to Bone and Osteolytic Bone Degradation [PDF]

Genes and Cancer, 2012
Oncostatin M (OSM) is an interleukin-6 (IL-6) family cytokine that has been implicated in a number of biological processes including inflammation, hematopoiesis, immune responses, development, and bone homeostasis.
Anderson, Robin, Aranda, Patrick S., Bolin, Celeste, Jorcyk, Cheryl, Moselhy, Jim, Redshaw, Jeff, Sutherland, Caleb, Tawara, Ken   +7 more
core   +4 more sources

The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review [PDF]

Open Life Sciences
Retinal diseases, which can lead to significant vision loss, are complex conditions involving various cellular and molecular mechanisms. The interleukin-6 (IL-6) family, particularly Oncostatin M (OSM), has garnered attention for their roles in retinal ...
Mori Tommaso, Nagaraj Nareshkumar Ragavachetty, Surico Pier Luigi, Zhou Wenjing, Parmar Uday Pratap Singh, D’Esposito Fabiana, Gagliano Caterina, Musa Mutali, Zeppieri Marco   +8 more
doaj   +2 more sources

The IL-22-oncostatin M axis promotes intestinal inflammation and tumorigenesis. [PDF]

Nat Immunol
Cineus R, Luo Y, Saliutina M, Manna S, Cancino CA, Velasco Blázquez L, Wang L, Bösel D, Abdelrahman A, Klementowicz JE, Scherl A, Hainbuch S, Bréart B, Kwon G, Konopka A, Guerra GM, von Coburg E, Gerbeth L, Roels J, Heinrich F, Müller N, Durek P, Deigendesch N, Ziai J, Hung J, Conrad T, TRR241 IBDome Consortium, Kühl AA, Wirtz S, Löhning M, Keir M, Diefenbach A, Mashreghi MF, Siegmund B, Schumann M, Romagnani C, West NR, Hegazy AN.   +37 more
europepmc   +3 more sources

Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M [PDF]

Immunity, 2021
M. Elizabeth Deerhake, Keiko Danzaki, Makoto Inoue, Emre Cardakli, Toshiaki Nonaka, Nupur Aggarwal, William E. Barclay, Ru‐Rong Ji, Mari L. Shinohara   +8 more
openalex   +3 more sources

Development of the First Small-Molecule Inhibitor Targeting Oncostatin M for Treatment of Breast Cancer. [PDF]

J Med Chem
Wolf CL, Feci A, Tuccinardi JP, Coughlin GH, Holdaway KA, Muhammed T, Pruett C, Lighter D, McGrath C, Engmann T, Pou-Torres M, Rushing B, Woodbury L, Haile SE, Scott H, Tawara K, Dinca S, Xu D, King MD, Warner LR, Jorcyk CL, Warner DL.   +21 more
europepmc   +2 more sources

Oncostatin M Measurement [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources