Results 41 to 50 of about 5,557 (173)

OSM and RCCS independently and synergistically induce the transcription of IL-6.

, 2015
MC3T3-E1 pre-osteoblasts were cultured with OSM supplementation and RCCS for 7 days. RNA was collected at 12 h, 48 h, and 7 d. Semi-quantitative RT-PCR was conducted for the cytokines and receptors most closely associated with OSM in osteoblasts, listed ...
Ken Tawara (748035), Julia Thom Oxford (748038), Danielle Hedeen (748036), Cheryl L. Jorcyk (748039), Jake Goyden (748034), Jeffrey S. Willey (748037)   +5 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S259-S306, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Chloe J. Peach, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Laura Kilpatrick, Doris Koesling, Michaela Kuhn, Birgit Leitinger, David MacEwan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes‐Peter Stasch, Scott A. Waldman   +31 more
wiley   +1 more source

Epileptogenesis in meningioma: Theories, putative biomarkers, and postoperative risk

Epilepsia, Volume 66, Issue 11, Page 4079-4090, November 2025.
Abstract Cranial meningioma are the most common type of primary brain tumor, and focal onset, tumor‐related seizures affect a significant proportion of patients. Seizures affect 30% of symptomatic preoperative patients and a further 12% of postoperative patients.
William H. Cook, Conor S. Gillespie, Ali Bakhsh, Anthony G. Marson, Michael D. Jenkinson, Adel E. Helmy   +5 more
wiley   +1 more source

Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes.

Journal of Biological Chemistry, 1994
Leukemia inhibitory factor (LIF) and oncostatin M (OSM) both bind to the same receptor with high affinity and thus mediate an overlapping spectrum of biological activities, the signal transduction mechanisms for which are unclear.
B. Thoma, T. Bird, D. Friend, D. Gearing, S. Dower   +4 more
semanticscholar   +1 more source

OSM Regulation of Responses to TLR-ligands in HASMC [PDF]

, 2012
Allergic atopic asthma is a respiratory condition that involves immune responses to specific allergens resulting in coughing, wheezing, shortness of breath and tightness in the chest.
Guerette, Jessica
core  

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source

Oncostatin M, through activation of Shc1, is a more potent inducer of RANKL expression and osteoclast differentiation than Leukemia Inhibitor Factor

, 2020
Reações inflamatórias crônicas próximas ao tecido ósseo geralmente levam à perda de estrutura tecidual, como no caso da artrite reumatoide e periodontite.
Marcelino, Thaís Floriano
core  

Surface Reconstruction in Quasi‐2D Perovskite Films Treated with Cesium Halide Nanocrystals: Halide Exchange or Phase Transformation

Small Science, Volume 5, Issue 9, September 2025.
Surface modification of quasi‐2D perovskite films with CsX (X = Cl, Br, I) nanocrystals enables tunable photoluminescence across the visible spectrum. Selective halide exchange or structural phase transformation occurs at the interface, governed by kinetic differences.
Dong Il Son, Seonhong Min, Sohyeon An, Dongryeol Lee, Se Hyun Lee, Donghan Kim, Myoung Hoon Song, Jin Young Kim, Sungwook Park, Junsang Cho, Jongnam Park   +10 more
wiley   +1 more source

Oncostatin M and the Interleukin-6 and Soluble Interleukin-6 Receptor Complex Regulate α1-Antichymotrypsin Expression in Human Cortical Astrocytes*

Journal of Biological Chemistry, 1998
α1-Antichymotrypsin (ACT) is an acute phase protein expressed in the brain which specifically colocalizes with amyloid-β during Alzheimer’s disease. We analyzed ACT synthesis in cultured human cortical astrocytes in response to various cytokines and ...
T. Kordula, R. Rydel, E. Brigham, F. Horn, P. Heinrich, J. Travis   +5 more
semanticscholar   +1 more source

The effects of the OSM and LIF proteins on the Growth of K562 cells and the HepG2 cells

, 2007
細胞激素（cytokine）是影響細胞生長、分化與細胞之間相互傳遞訊息的因子，受到刺激後會快速合成。多數細胞素具有多種生物活性，即一種細胞素可以作用於不同細胞，有許多不同的功能，不同的細胞素之間也可能有相同或相似的功能。Oncostatin M（OSM）以及Leukemia inhibitory factor（LIF）都屬於Interleukin-6（IL-6）細胞激素家族（Cytokine family）的一員。LIF可以維持幹細胞的未分化狀態，在其他細胞卻有誘導分化的作用 ...
Yang, Hui-Wen, 楊蕙雯
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