Results 31 to 40 of about 5,557 (173)

Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases

MedComm, Volume 7, Issue 3, March 2026.
This study examined hemidesmosome assembly‐related genes in pemphigoid diseases, revealing variants linked to disease onset and severity. Functional analyses, including Caenorhabditis elegans models, Ker‐CT transcriptomics, human proteomics, etc., demonstrated that ITGA6 mutations destabilize hemidesmosomes, disrupt dermal–epidermal adhesion, and ...
Shan Cao, Tianyu Wang, Chen Lv, Shanshan Ma, Gongqi Yu, Qianqian Xia, Tingting Liu, Yueqian Yu, Lele Sun, Xiaoyan Pei, Qing Zhao, Zhenzhen Wang, Chuan Wang, Yongxia Liu, Shengli Chen, Jianwen Wang, Guizhi Zhou, Hong Liu, Yonghu Sun, Furen Zhang   +19 more
wiley   +1 more source

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, Volume 125, Issue 3, Page 185-202, March 2026.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

LIF and BMP4 regulate eIF2α phosphorylation and translation initiation.

, 2015
A model for how LIF and BMP4 regulate translation initiation. LIF and BMP4 bind receptors on the cell surface leading to decreased CReP and increased PKR activity respectively. LIF signals to phosphorylate eIF4G via an unknown pathway.
Kyle Friend (799951), Judith Kimble (90747), Nicholas E. Propson (799953), Hunter A. Brooks (799952), James A. Thomson (386646)   +4 more
core   +1 more source

GP130 cytokines and bone remodelling in health and disease.

BMB Reports, 2010
Cytokines that bind to and signal through the gp130 co-receptor subunit include interleukin (IL)-6, IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), and ciliary neutrophic factor (CNTF).
N. Sims, N. Walsh
semanticscholar   +1 more source

Novel Genetic Findings in Stuve‐Wiedemann Syndrome: A Case Report and Review of Literature

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Stuve‐Wiedemann Syndrome (SWS) is a rare autosomal recessive condition, first reported in 1971 by Stuve and Wiedemann. It is associated with pathogenic or likely pathogenic homozygous or compound heterozygous variants in the Leukemia Inhibitory Factor Receptor (LIFR) gene.
Khalid Hamasalih Hamasharef, Zana Baqi Najmadden, Rozhgar AKhailany, Muhammad Jabar Rashid, Kaiwan Hamakarim   +4 more
wiley   +1 more source

Data_Sheet_1_Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor.PDF

, 2019
Background and Purpose: The gp130 family of cytokines signals through receptors dimerizing with the gp130 subunit. Downstream signaling typically activates STAT3 but also SHP2/Ras/MAPK pathways.
Thais Floriano-Marcelino (6742484), Howard Herschel Conaway (6742487), Ulf H. Lerner (6742490), Emma Persson (362368), Ulf H. Lerner, Emma Persson, Thais Floriano-Marcelino, Petra Henning (27522), Howard Herschel Conaway, Petra Henning, Pedro P. C. Souza (6742481), Pedro P. C. Souza   +11 more
core   +1 more source

STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT The conserved aspartic acid residue D661 within the STAT3 SH2 domain is a recurrent mutational hotspot in hematologic malignancies, including T‐cell large granular lymphocytic leukaemia, myelodysplastic syndromes and acute lymphoblastic leukaemia. To define the functional consequences of distinct STAT3D661 variants, we integrated computational,
Hye Kyung Lee, Gyuhyeok Cho, Jichun Chen, Aaron B. Schultz, Sung‐Gwon Lee, Chengyu Liu, Priscilla A. Furth, Neal S. Young, Jungwook Kim, Alejandro Villarino, Lothar Hennighausen   +10 more
wiley   +1 more source

Intracellular Detection of C. acnes and S. aureus in Non‐Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways

JOR SPINE, Volume 8, Issue 4, December 2025.
Cutibacterium acnes and Staphylococcus aureus antigens were detected within non‐herniated intervertebral discs and correlated with catabolic and pyroptotic markers (MMP‐3, GSDMD) and PRRs including NOD2. NP cells exposed to bacterial peptidoglycan showed MAPK/NF‐κB activation and catabolic cytokine release, suggesting that bacterial sensing through a ...
Andrea Nüesch, Exarchos Kanelis, Leonidas G. Alexopoulos, Benjamin Gantenbein, Melissa Lacey, Christine L. Le Maitre   +5 more
wiley   +1 more source

Intrauterine expression of LIF and its receptors in the cycling and early pregnant mare [PDF]

, 2009
Leukaemia Inhibitory Factor (LIF) plays a critical role in blastocyst development and implantation, as clearly demonstrated by the failure of wild-type mouse embryos to implant in the uterus of LIF-knockout female mice unless the latter receive LIF ...
Paris, Damien B.B.P., Villani, Marta, Stout, Tom A.E., Vriend, Bianca A.M.   +3 more
core  

Understanding the Physiological Behavior of Disc Cells in an In Vitro Imitation of the Healthy and Degenerated Disc Niche

JOR SPINE, Volume 8, Issue 4, December 2025.
Here, the development of media compositions to mimic the healthy and degenerate IVD has been achieved. Human NP cells and explants were successfully cultured within these media without any detectable loss of viability and minimal secretomic changes. The main effects observed within cultures were seen with the addition of physiological concentrations of
Joseph Snuggs, Shaghayegh Basatvat, Exarchos Kanelis, Abbie Binch, Leonidas Alexopoulos, Marianna A. Tryfonidou, Christine Le Maitre   +6 more
wiley   +1 more source