Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype
Journal of Neuroinflammation, 2017 Background The consumption of large amounts of dietary fats can trigger an inflammatory response in the hypothalamus and contribute to the dysfunctional control of caloric intake and energy expenditure commonly present in obesity.
Milena Fioravante +8 more
doaj +3 more sources
Leukemia inhibitory factor and its role in physiologic and pathological processes [PDF]
MedUNAB, 2006 Leukemia inhibitory factor (LIF) is celular comunication mediator that shows a very wide range of biologic activities that include the cell differentiation, cell growth and proliferation, cell trophic and anti-apoptotic effect, cell protection of ...
Grégory Alfonso García +5 more
doaj +2 more sources
Recombinant purified buffalo leukemia inhibitory factor plays an inhibitory role in cell growth. [PDF]
PLoS ONE, 2018 Leukemia Inhibitory Factor (LIF) is a polyfunctional cytokine, involved in numerous regulatory effects in vivo and in vitro, varying from cell proliferation to differentiation, and has therapeutic potential for treating various diseases.
Syed Azmal Ali +4 more
doaj +1 more source
Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure
Reproductive Biology and Endocrinology, 2021 Objective The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus.
Li Zhou +3 more
doaj +1 more source
, 2022 Testicular Leydig cells (LCs) are the principal source of circulating testosterone in males. LC steroidogenesis maintains sexual function, fertility and general health, and is influenced by various paracrine factors.
Curley, M +9 more
core +1 more source
Polarized secretion of Leukemia Inhibitory Factor
BMC Cell Biology, 2008 Background The direction of cytokine secretion from polarized cells determines the cytokine's cellular targets. Leukemia inhibitory factor (LIF) belongs to the interleukin-6 (IL-6) family of cytokines and signals through LIFR/gp130.
Vernallis Ann B, Hill Eric J
doaj +1 more source
Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]
, 2002 Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
George K. Tofaris +7 more
core +1 more source
Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]
, 2004 Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Kopp, F. B. +10 more
core +1 more source
, 2023 To explore the association of leukemia inhibitory factor receptor (LIFR) gene variant rs3099124, ovarian steroids, and leukemia inhibitory factor with unexplained infertility in Pakistani females.
Mehir un Nisa Iqbal (14801370) +3 more
core +2 more sources
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction. [PDF]
PLoS ONE, 2016 Cardiac stem cells or precursor cells regenerate cardiomyocytes; however, the mechanism underlying this effect remains unclear. We generated CreLacZ mice in which more than 99.9% of the cardiomyocytes in the left ventricular field were positive for 5 ...
Masato Kanda +10 more
doaj +1 more source