Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype
Journal of Neuroinflammation, 2017 Background The consumption of large amounts of dietary fats can trigger an inflammatory response in the hypothalamus and contribute to the dysfunctional control of caloric intake and energy expenditure commonly present in obesity.
Milena Fioravante +8 more
doaj +3 more sources
Leukemia inhibitory factor and its role in physiologic and pathological processes [PDF]
MedUNAB, 2006 Leukemia inhibitory factor (LIF) is celular comunication mediator that shows a very wide range of biologic activities that include the cell differentiation, cell growth and proliferation, cell trophic and anti-apoptotic effect, cell protection of ...
Grégory Alfonso García +5 more
doaj +2 more sources
Leukemia inhibitory factor and its receptor: expression and regulation in the porcine endometrium throughout the estrous cycle and pregnancy [PDF]
Asian-Australasian Journal of Animal Sciences, 2019 Objective Leukemia inhibitory factor (LIF) binds to a heterodimeric receptor composed of LIF receptor (LIFR) and glycoprotein 130 (GP130) to transmit signals into the cell.
Inkyu Yoo +5 more
doaj +1 more source
The Regulation of Leukemia Inhibitory Factor [PDF]
Cancer Cell & Microenvironment, 2015 Leukemia inhibitory factor (LIF), a secreted cytokine, plays an important role in a wide array of biological processes including inducing differentiation of leukemia cell, inflammatory response, neuronal development, embryonic implantation, stem cell self-renewal and cancer progression, etc.
Xuetian, Yue, Lihua, Wu, Wenwei, Hu
openaire +2 more sources
Effect of Different Concentrations of Leukemia Inhibitory Factor on Gene Expression of Vascular Endothelial Growth Factor-A in Trophoblast Tumor Cell Line [PDF]
International Journal of Fertility and Sterility, 2020 Background Several studies have shown that leukemia inhibitory factor (LIF) is one of the most important cytokines participating in the process of embryo implantation and pregnancy, while, the role of this factor on vascular endothelial factor-A (VEGF ...
Khodakaram Jahanbin +2 more
doaj +1 more source
Recombinant purified buffalo leukemia inhibitory factor plays an inhibitory role in cell growth. [PDF]
PLoS ONE, 2018 Leukemia Inhibitory Factor (LIF) is a polyfunctional cytokine, involved in numerous regulatory effects in vivo and in vitro, varying from cell proliferation to differentiation, and has therapeutic potential for treating various diseases.
Syed Azmal Ali +4 more
doaj +1 more source
Targeting the Leukemia Inhibitory Factor/Leukemia Inhibitory Factor Receptor Axis Reduces the Growth of Inflammatory Breast Cancer by Promoting Ferroptosis. [PDF]
Cancers (Basel)Background: Inflammatory breast cancer (IBC) is a rare subtype of breast cancer accounting for 7% of breast cancer-related fatalities. There is an urgent need to develop new targeted treatments for IBC.
Romo B +13 more
europepmc +2 more sources
, 2022 Testicular Leydig cells (LCs) are the principal source of circulating testosterone in males. LC steroidogenesis maintains sexual function, fertility and general health, and is influenced by various paracrine factors.
Curley, M +9 more
core +1 more source
, 2023 To explore the association of leukemia inhibitory factor receptor (LIFR) gene variant rs3099124, ovarian steroids, and leukemia inhibitory factor with unexplained infertility in Pakistani females.
Mehir un Nisa Iqbal (14801370) +3 more
core +2 more sources
Solution Structure of Leukemia Inhibitory Factor [PDF]
Journal of Biological Chemistry, 1998 The solution structure of a murine-human chimera of leukemia inhibitory factor (LIF), a 180-residue cytokine with a molecular mass of 20 kDa, has been determined using multidimensional heteronuclear NMR techniques. The protein contains four alpha-helices, the relative orientations of which are well defined on the basis of long-range interhelical ...
M G, Hinds +4 more
openaire +2 more sources