Results 141 to 150 of about 692,170 (234)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Life's simple 7 and its association with trajectories in depressive symptoms among urban middle-aged adults. [PDF]

J Affect Disord, 2023
Beydoun MA, Georgescu MF, Hossain S, Beydoun HA, Fanelli-Kuczmarski MT, Evans MK, Zonderman AB.   +6 more
europepmc   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Temporal Trends in Cardiovascular Health Metrics in Italy, 2015–2024: A Ten-Year Report from the Longevity Check-Up (Lookup) 8+ Study

Medical Sciences
Background/Objectives: The objective of this ten-year report is to describe temporal trends in the cardiovascular health (CVH) score and its individual components across ages and sexes. We also examined the impact of the post-COVID-19 period on ideal CVH
Stefano Cacciatore, Elena Levati, Riccardo Calvani, Matteo Tosato, Francesca Ciciarello, Vincenzo Galluzzo, Sara Salini, Andrea Russo, Emanuele Marzetti, Francesco Landi   +9 more
doaj   +1 more source

Jim Agard: A Retrospective

, 2012
The subject of illusion has been at the core of Jim’s work from the get-go. So when he serendipitously met some guy one night who was toying with a bent hanger, insisting Jim entertain him by seeing if he could visually make the wire cube turn inside out,
Agard, James D., Rosenstein, Kerri R.
core  

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Improving mental health in black men through a 24-week community-based lifestyle change intervention: the black impact program

BMC Psychiatry
Background Poor mental health is a leading cause of morbidity and mortality among Black men in the United States. Efforts to improve mental health among Black men have been hampered by a lack of access and utilization of mental health services.
Joshua J. Joseph, Timiya S. Nolan, Guy Brock, Amaris Williams, Songzhu Zhao, Alicia McKoy, Bjorn Kluwe, Faith Metlock, Katherine Campanelli, James B. Odei, Monique T. Khumalo, Dana Lavender, John Gregory, Darrell M. Gray   +13 more
doaj   +1 more source

Ideal Life's Simple 7 Score Relates to Macrovascular Structure and Function in the Healthy Population. [PDF]

Nutrients, 2022
Nève G, Wagner J, Knaier R, Infanger D, Klenk C, Carrard J, Hinrichs T, Hanssen H, Schmidt-Trucksäss A, Königstein K.   +9 more
europepmc   +1 more source

Life's Essential 8 and Life's Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project.

Mayo Clinic proceedings, 2023
Ángel Herráiz-Adillo, Sara Higueras-Fresnillo, V. Ahlqvist, D. Berglind, Maria B. Syrjälä, B. Daka, Cecilia Lenander, Johan Sundström, Francisco B. Ortega, C. Östgren, K. Rådholm, P. Henriksson   +11 more
semanticscholar   +1 more source