Results 71 to 80 of about 901,616 (214)
Kazantzakis-Nietzsche, un discipulado vital Kazantzakis-Nietzsche, a vital discipleship
El trabajo aborda desde diversos ángulos la relación ideológica y humana entre Kazantzakis y el filósofo Nietzsche. Fue el escritor griego quien se sintió atraído y hasta identificado con la figura de Nietzsche. En el terreno de las ideas, Nietzsche dejó
Roberto Quiroz Pizarro
doaj
MEMOIRS IN VERSE BY THE POET ARSTANBEK [PDF]
The article gives an overview of memories of the works, poems of the poet-improviser Arstanbek, who can be called the nightingale of the Kyrgyz people.
Alpaizova B. S.
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We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Death and Spirit in Hegel’s Philosophy of Nature
The text discusses the problem of the relationship between nature and thinking in Hegel’s Encyclopaedia of the Philosophical Sciences (1830). By considering the dialectics of natural life and the significance of death of the individual for the emergence
Brigita Gelžinytė
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