Results 91 to 100 of about 3,899,122 (312)
Developing an Agenda for Change for New Jersey's Urban Water Infrastructure [PDF]
, 2014 A water infrastructure crisis looms in New Jersey's oldest and largest cities -- cities that comprise nearly one-fifth of the state's population and are projected to absorb much of its future growth, and yet have combined sewer systems, which carry both ...
core
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Ontogeny influences sensitivity to climate change stressors in an endangered fish. [PDF]
, 2014 Coastal ecosystems are among the most human-impacted habitats globally, and their management is often critically linked to recovery of declining native species.
Castillo, G +6 more
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Adaptando mi vida: vivencias de cuidadores familiares de personas con enfermedad de Alzheimer
GerokomosRESUMEN La enfermedad de Alzheimer (EA) es una de las demencias más comunes y afecta al 8% de la población mayor de 65 años y al 30% de la población mayor de 80 años en los países con una alta expectativa de vida. Esta enfermedad es devastadora tanto por
Miriam Rubio Acuña +3 more
doaj
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Reflections on Retirement: The Sunset Can be Spooktacular!
Philippine Journal of Otolaryngology Head and Neck SurgeryWhere are we headed, oh, where have we gone? We’ve come a long way, now, let us move on. Dreams are for dreaming, wake up and they run, Life is for living, come, let us move on.1 1JF Lapena, Moving on Retirement (n.); from French ...
José Florencio Lapeña
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Two Economists' Musings on the Stability of Locus of Control [PDF]
Empirical studies of the role of non-cognitive skills in driving economic behavior often rely heavily on the assumption that these skills are stable over the relevant time frame. We analyze the change in a specific non-cognitive skill, i.e.
Deborah Cobb-Clark, Stefanie Schurer
core +3 more sources
Brain SciencesBackground/Objectives: The aim of this pilot study is to qualitatively describe the use of life history questionnaires in an acute neurorehabilitation setting to define individualised goals of care for patients with clinical cognitive motor dissociation ...
Yago Rodriguez Mateos +5 more
doaj +1 more source