Results 221 to 230 of about 5,863,535 (304)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Sex differences in antibody responses to influenza A/H3N2 across the life course

Metcalf CJ, Chen S, García-Carreras B, Hay J, Zhu H, Jiang C, Kwok K, Riley S, Read J, Lessler J, Cummings D.   +10 more
europepmc   +1 more source

Homelessness in pregnancy: life course factors and mental health in the context of COVID-19. [PDF]

Front Psychiatry
Jeffers NK, Arno CA, McShane KS, Vanderpuije M, Lozano A, Bradford HM, Shasanmi-Ellis R, Grace KT, Robinson KN, Marea CX.   +9 more
europepmc   +1 more source

An interdisciplinary fetal neonatal neurology collaborative promotes integrative life-course brain health. [PDF]

Front Neurol
Scher MS, Eyre H, Donn S, Roberts JM, Msall ME, Salafia CM, Towbin R, Robinson P, Loparo K, Berk M, Moro E, Smith V, Ludington S, Badawi N, Hunt RW, Gunn A, Sarnat HB, Kunikullaya K, Pilon B.   +18 more
europepmc   +1 more source