Results 111 to 120 of about 1,893,984 (290)

Simulation aided life cycle sustainability assessment framework for manufacturing design and management [PDF]

, 2016
Decision making for sustainable manufacturing design and management requires critical considerations due to the complexity and partly conflicting issues of economic, social and environmental factors.
Gbededo, Mijoh Ayodele, Liyanage, Kapila, Oraifige, Ilias   +2 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Organic farming without fossil fuels - life cycle assessment of two Swedish cases [PDF]

, 2013
Organic agriculture is dependent on fossil fuels, just like conventional agriculture, but this can be reduced by the use of on-farm biomass resources. The energy efficiency and environmental impacts of different alternatives can be assessed by life cycle
Baky, A., Hansson, P.-A., Kimming, M., Nordberg, Å., Sundberg, C.   +4 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Adoption model of eco-friendly livestock innovation for beef cattle sustainability in dry climate regions

Environmental and Sustainability Indicators
Beef cattle farming plays an important role in improving rural economies, especially in arid climates that often face complex ecological, social and economic challenges.
Ture Simamora, Paulus Klau Tahuk, Muhamad Nasir Rofiq, Ody Wolfrit Matoneng, Stefanus Sio, Lalu Muhamad Risman Dwi Jumansyah, Brigida Antonia Correia, Ligia Tomas Correia   +7 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Blockchain and big data integration design for traceability and carbon footprint management in the fishery supply chain

Egyptian Informatics Journal
The utilization of blockchain technology in the fishing industry has been extensively studied and implemented to address issues such as illegal fishing and carbon emissions control.
Aslan Alwi, Nugroho Adi Sasongko, Suprapto, Yaya Suryana, Hendro Subagyo   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Performa Tungku Hibrid Energi Surya dan Gas untuk Alat Pengering Kabinet dengan Sistem Cerdas

Jurnal Ilmiah Rekayasa Pertanian dan Biosistem
Tujuan dari penelitian ini adalah untuk mengevaluasi kinerja alat pengering kabinet yang menggunakan hibrid energi surya dan LPG. Energi terbarukan sangat penting untuk pengeringan pertanian.
Indonesia Indonesia, Mursalim Mursalim, Anugerah Fitri Amalia   +2 more
doaj   +1 more source