Results 131 to 140 of about 533,744 (303)

A comparative nutritional life cycle assessment of processed and unprocessed soy-based meat and milk alternatives including protein quality adjustment

Frontiers in Sustainable Food Systems
Efforts towards sustainable food systems have stimulated the development of plant-based alternatives to meat and milk. However, the debate on the nutritional quality of (processed) plant products compared to animal products remains unresolved, and ...
Moritz Herrmann, Eric Mehner, Lotti Egger, Reto Portmann, Laila Hammer, Laila Hammer, Laila Hammer, Thomas Nemecek   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Fish for food or food for fish? Use of material flow analysis to optimize protein availability of seafood products for human consumption

Future Foods
The growing pressure on pelagic resources and the dilemma of redirecting high-nutritional whole fish to aquafeed, stress the need for quantitative evidence to maximize marine-protein availability for human consumption.
David Baptista de Sousa, Ramzy Kahhat, Ian Vázquez-Rowe   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Assessing agricultural soil acidification and nutrient management in life cycle assessment

, 2011
This paper describes part of the first detailed environmental life cycle assessment (LCA) of Australian red meat (beef and sheep meat) production.
Gregory M. Peters, Tucker, R., Feitz, A. J., Rowley, H. V., Peters, Gregory, Stephen Wiedemann, Schulz, M., Peters, Gregory,, Andrew J. Feitz, Wiedemann, S., Matthias Schulz, Robyn Tucker, Hazel V. Rowley   +12 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Adoption model of eco-friendly livestock innovation for beef cattle sustainability in dry climate regions

Environmental and Sustainability Indicators
Beef cattle farming plays an important role in improving rural economies, especially in arid climates that often face complex ecological, social and economic challenges.
Ture Simamora, Paulus Klau Tahuk, Muhamad Nasir Rofiq, Ody Wolfrit Matoneng, Stefanus Sio, Lalu Muhamad Risman Dwi Jumansyah, Brigida Antonia Correia, Ligia Tomas Correia   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hotspot identification in the clothing industry using social life cycle assessment - opportunities and challenges of input-output modelling

, 2018
A cradle-to-gate, input/output-based social life cycle assessment (SLCA) was conducted using the Swedish clothing consumption as a case study. The aim was to investigate the influence of the cut-off rule and the definition of "hotspots" in social hotspot
Sandin, Gustav A, Peters, Gregory,, Zamani, Bahareh,, Sandin, Gustav,, Svanström, Magdalena,, Zamani, Bahareh, Svanstr\uf6m, Magdalena, Sandin, Gustav A,, Peters, Gregory, Peters, Gregory M.,   +9 more
core   +1 more source