Results 81 to 90 of about 897,525 (296)

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan   +5 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Life Cycle Assessment and Life Cycle Costing for PSS [PDF]

open access: yes, 2018
The increasing awareness towards sustainability issues from both practitioners and customers makes it necessary to adopt a lifecycle perspective since the design phase of PSSs. In this chapter, a tool aimed at carrying out the Life Cycle Assessment (called MaGA) and one for the Life Cycle Costing (called BAL.LCPA) are introduced starting from the ...
Corti, Donatella   +4 more
openaire   +2 more sources

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

How Traditional Costing Methods Hinder the Development of Modular Product Architectures

open access: yesApplied Sciences
This study investigates how traditional costing methods hinder the development of modular product architectures. A structured literature review identifies the gap between Management Accounting (MA) and Innovation and Operations Management (IOM ...
Morten Nørgaard   +3 more
doaj   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi   +17 more
wiley   +1 more source

THE DEVELOPMENT OF SUSTAINABLE DESIGN DECISION TOOL FOR PUBLIC BUILDINGS IN INDONESIA

open access: yesTeras Jurnal: Jurnal Teknik Sipil, 2016
Sustainable building has become a catchphrase in many countries. Issue on sustainability has attracted researchers from industry and academia in recent years, and the number is still growing. Despite different definitions of sustainable building, quality
Hamdi Akmal Lubis
doaj   +1 more source

Lessons Learned from Life Cycle Assessment and Life Cycle Costing of Two Residential Towers at the University of British Columbia

open access: yes, 2018
The University of British Columbia has an interest in incorporating life cycle environmental impacts and financial information into project planning, as well as research and teaching.
Zahra Teshnizi   +4 more
semanticscholar   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Agricultural life cycle assessment: a system-wide bibliometric research

open access: yesAgricultural and Resource Economics
Purpose. This paper aims to give a system-wide overview of agricultural life cycle assessment (LCA), based on the understanding of agriculture as a complex providing humanity with food, energy and other vital resources and considering all forms of sector’
Inna Koblianska   +2 more
doaj   +1 more source

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