Results 41 to 50 of about 1,232,833 (305)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Life cycle costs of construction object [PDF]

open access: yes, 2013
Každé stavební dílo prochází svým životním cyklem, od počáteční myšlenky, přes jeho projektování, realizaci, případně změnu stavby a užívání až po jeho odstranění.
Beránková, Eva, Szkanderová, Lenka
core  

Greenhouse Gas Reduction Opportunities for Local Governments: A Quantification and Prioritization Framework [PDF]

open access: yes, 2020
Local governments have steadily increased their initiative to address global climate change, and many present their proposed strategies through climate action plans (CAPs). This study conducts a literature review on current local approaches to greenhouse
Butt, Ali A.   +5 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Life Cycle Costs and Life Cycle Assessment for the Harvesting, Conversion, and the Use of Switchgrass to Produce Electricity

open access: yesInternational Journal of Chemical Engineering, 2013
This paper considers both LCA and LCC of the pyrolysis of switchgrass to use as an energy source in a conventional power plant. The process consists of cultivation, harvesting, transportation, storage, pyrolysis, transportation, and power generation ...
Nuttapol Lerkkasemsan   +1 more
doaj   +1 more source

Life Cycle Costs & Housing Affordability Measurement [PDF]

open access: yes, 2010
This paper examines current problems with home ownership affordability measurement and presents an innovative affordability measurement model that incorporates a comprehensive assessment and risk analysis of housing life cycle costs. The main method used
Smith, PV
core  

Life-cycle costing of metallic structures [PDF]

open access: yes, 2007
Structural material selection has traditionally been based on Initial material cost. However, growing pressure on the construction industry to consider the longer-term financial and environmental implications of projects is encouraging a more holistic ...
Cruise, RB   +4 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Modelling of life cycle cost of conventional and alternative vehicles

open access: yesScientific Reports, 2022
Over the past decade, the passenger transport segment has undergone significant changes, particularly in the way vehicles are propelled. These changes have been influenced by the global drive to reduce the environmental burden associated with the ...
Jan Furch   +2 more
doaj   +1 more source

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