Results 151 to 160 of about 908,324 (360)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Life-Cycle Modeling of Structural Defects via Computational Geometry and Time-Series Forecasting. [PDF]
Sensors (Basel), 2019 Mohamadi S, Lattanzi D.
europepmc +1 more source
Trend-Reverting Fluctuations in the Life-Cycle Model [PDF]
, 1998 Costas Azariadis +2 more
openalex +1 more source
Vision for Cross-Center MSBE Collaboration on the Gateway Program [PDF]
Model-Based Systems Engineering (MBSE) can be a challenge when there is only one modeler and one model involved. For the Gateway Program, due to its unique acquisition approach, the modeling efforts involve multiple NASA centers with each developing ...
Crane, Jeremiah +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Life-cycle models and security threats to the microchip during its development and exploitation
, 2023 Danila S. Belyakov +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source