Results 181 to 190 of about 908,324 (360)

Integration of automatic generated simulation models, machine control projects and management tools to support whole life cycle of industrial digital twins.

, 2019
Julio Garrido Campos, J. Sáez
openalex   +1 more source

Assessment, development, and application of combustor aerothermal models [PDF]

The gas turbine combustion system design and development effort is an engineering exercise to obtain an acceptable solution to the conflicting design trade-offs between combustion efficiency, gaseous emissions, smoke, ignition, restart, lean blowout ...
Holdeman, J. D., Mongia, H. C., Mularz, E. J.   +2 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Low Cycle Fatigue Life Assessment of Alloy 617 Weldments at 900℃ by Coffin-Manson and Strain Energy Density-Based Models

, 2017
Tungga Dewa Rando, Seon–Jin Kim
openalex   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity. [PDF]

J Virol, 2014
Watt A, Moukambi F, Banadyga L, Groseth A, Callison J, Herwig A, Ebihara H, Feldmann H, Hoenen T.   +8 more
europepmc   +1 more source

Business Process Modeling of the Pesticide Life Cycle: a service-oriented approach [PDF]

, 2009
Beulens, A.J.M., Matocha, D., Verloop, C.M., Wolfert, J.   +3 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A data-driven life cycle cost model for tender evaluation of metro pantograph carbon strips. [PDF]

Sci Rep
Liu J, Wu C.
europepmc   +1 more source