Results 191 to 200 of about 174,427 (313)

Environmental Assessment and Eco-Efficiency of Airport Pavements Incorporating Warm RAP Base Layers. [PDF]

Materials (Basel)
Junior WC, Santos TR, Senra VSM, Maia MA, Nascimento FACD, Guimarães ACR, Neves Monteiro S, Coelho LM.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Low-Cycle Fatigue Life Prediction Method for a Drive Shaft Considering the Effects of Loading and Strength Degradation. [PDF]

Materials (Basel)
Yang L, Yu X, Liu F, Wang L, Zhang J, Zhang X, Zhang J.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A data-driven life cycle cost model for tender evaluation of metro pantograph carbon strips. [PDF]

Sci Rep
Liu J, Wu C.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Correction: Nutritional life cycle assessment for healthy and sustainable food systems: evidence and policy insights from Africa and Asia. [PDF]

Front Nutr
McAuliffe GA, Ortenzi F, van der Pols JC, Nemecek T, Colston J, Beal T.   +5 more
europepmc   +1 more source

A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity. [PDF]

J Virol, 2014
Watt A, Moukambi F, Banadyga L, Groseth A, Callison J, Herwig A, Ebihara H, Feldmann H, Hoenen T.   +8 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

D5.2 – Life Cycle Model

The purpose of this document is to create two life cycle models, on which develop and test the future design of the current limiter device. The first model is created to evaluate the social risks arising from the value chain of producing the InSb-Printed Circuit Board (PCB) that will be part of the final Current Limiter device, whilst the second model
openaire   +1 more source