Results 131 to 140 of about 427,526 (314)

Life cycle stages, specific organelles and invasion mechanisms of Eimeria species. [PDF]

Parasitology, 2020
Burrell A, Tomley FM, Vaughan S, Marugan-Hernandez V.   +3 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The impact of Spodoptera exigua herbivory on Meloidogyne incognita-induced root responses depends on the nematodes' life cycle stages. [PDF]

AoB Plants, 2020
Mbaluto CM, Ahmad EM, Fu M, Martínez-Medina A, van Dam NM.   +4 more
europepmc   +1 more source

Employees’ Types of Intelligence Assessment Method in Accordance with the Elements of the Five-Factor Model Considering Life Cycle Stages

, 2022
LIANA CHERNOBAI, ELIZABETH KARSKA, YULIIA SHIRON   +2 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Some phytochemical changes inTaxus baccataL. shoots associated with stages in the life cycle ofTaxomyia taxiInch. [PDF]

, 1980
T. J. Lovett
openalex   +1 more source

DEVELOPMENT OF ECONOMIC MODELS OF THE DEVELOPMENT OF TECHNICAL SYSTEMS BY STAGES OF THE LIFE CYCLE

, 2021
IGOR I. MIKITENKO
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Life Cycle of Amphipyra livida corvina MATSCHULSKY (Lepidoptera: Noctuidae), with Special Reference to the Termination of Aestivation in the Adult Stage

, 1975
Ryokichi TSUGANE
openalex   +2 more sources

SUBSTANTIATION OF THE IMPACT OF LIFE CYCLE STAGES ON THE ORGANIZATION'S COMPETENCE STRUCTURE

, 2023
Інна Грузіна
openalex   +2 more sources