Results 91 to 100 of about 435,308 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Commentary: Non-linearity in LCA – What are we talking about?

Frontiers in Sustainability, 2022
Reinout Heijungs, Reinout Heijungs, Sangwon Suh, Sangwon Suh   +3 more
doaj   +1 more source

An application of hybrid life cycle assessment as a decision support framework for green supply chains [PDF]

, 2014
In an effort to achieve sustainable operations, green supply chain management has become an important area for firms to concentrate on due to its inherent involvement with all the processes that provide foundations to successful business.
A. Acquaye, A. Genovese, A. Lake, Bani M., Emmett S., Greenhouse Gas Protocol, Horne R., Mckinnon A., N. Kumar, Porter M. E., S.C.L. Koh, Sundarakani B., UNEP and SETAC, Yin R. K.   +13 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A dataset of characterization factors for biodiversity impact assessment in OpenLCA and LCA for expertsZenodo

Data in Brief
The accelerating loss of biodiversity and ongoing ecosystem degradation rank among the most pressing global challenges today. Life Cycle Assessment (LCA) has emerged as a pivotal tool for evaluating the environmental sustainability of production systems;
Julian Quandt, Jan Paul Lindner, Nico Mumm   +2 more
doaj   +1 more source

Assessing sustainability performance of built projects: a building process approach [PDF]

, 2010
Existing environmental performance assessment approaches focus on the overall performance to reflect sustainability of built projects. However, the impacts caused by construction activities on the environment occur throughout a project's life cycle which
Ding, GK, Shen, L
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Assessment of key sustainability indicators in a UK fast food supply chain: a life cycle perspective [PDF]

, 2012
The purpose of this article is to investigate the understanding of businesses and end consumers of key sustainability measures in the UK fast food Supply Chain.
Nabhani, Farhad, Oglethorpe, David, Shokri, Alireza   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

BIM-Based Life Cycle Sustainability Assessment for Buildings

Sustainability, 2022
The construction of buildings has a high level of environmental impacts [...]
openaire   +3 more sources