Results 81 to 90 of about 35,003 (262)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Energy poverty from a life cycle sustainability assessment perspective

Cleaner Environmental Systems
Energy poverty (EP) and energy security (ES) are complex, multi-dimensional challenges with profound environmental, economic, and social implications that persist in both developed and developing nations.
T.D. Gates, M. Hannouf, D. Gebremedhin, T.D. Beyene, G. Assefa, I.D. Gates   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

A Regional Evaluation of Sustainability with Special Regard to Social Aspect

Theory, Methodology, Practice, 2010
Today sustainable development is an organic part of the community policies of the European Union including regional policy. Sustainability is important not only for products and services, but also for regions.
Klára Szita Tóthné, Eszter Siposné Nándori   +1 more
doaj  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Supply Chains in the context of Life Cycle Assessment and Sustainability [PDF]

16th International Scientific Conference - Business Logistics in Modern Management: proceedings, 2016
Production and consumption of many products are subjected to a thorough study of their evident impact on local ecosystems and global warming, with the purpose of reduction their emissions, finding product and process alternatives and/or their total suspension or penalization.
Franjković, Jelena, Mesarić, Josip, Šebalj, Dario   +2 more
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Current scenario and potential of waste cooking oil as a feedstock for biodiesel production in Indonesia: Life cycle sustainability assessment (LCSA) review

Case Studies in Chemical and Environmental Engineering
WCO is a second-generation biofuel made up of accumulated free fatty acids, which can be used as feedstock for biodiesel production. The review aims to: (a) evaluate the sustainability of waste cooking oil (WCO) for biodiesel production in Indonesia ...
Arif Rahman, M.A.M. Oktaufik, Triyono Widi Sasongko, Iwan Guntoro, Dadi Soedjati, Najmi Abbas, Abdul Rahman, Fathiah Ulfah, Ari Widiarto, Siswanto, Dharmawan, Sudarwaji Edi Yuwono Trihadi, Kusrestuwardani, Anggara Lomak Prihatin, Adim Hadi, Surat Indrijarso, Priyambodo Rahardjo, Arief Barkah, Irhan Febijanto, Nugroho Adi Sasongko   +19 more
doaj   +1 more source