Results 141 to 150 of about 13,140,877 (372)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Imaging technologies and strategies for detection of extant extraterrestrial microorganisms

open access: yesAdvances in Physics: X, 2018
There is no reductionist definition of life, so the way organisms look, behave, and move is the most definitive way to identify extraterrestrial life.
Jay L. Nadeau   +2 more
doaj   +1 more source

A manned exobiology laboratory based on the Moon [PDF]

open access: yes
Establishment of an exobiology laboratory on the Moon would provide a unique opportunity for exploration of extraterrestrial materials on a long-term, ongoing basis, for elucidation of exobiological processes and chemical evolution.
Gehrke, Charles W.   +5 more
core   +1 more source

Semantics-driven event clustering in Twitter feeds [PDF]

open access: yes, 2015
Detecting events using social media such as Twitter has many useful applications in real-life situations. Many algorithms which all use different information sources - either textual, temporal, geographic or community features - have been developed to ...
De Boom, Cedric   +2 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

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