Results 161 to 170 of about 6,867,278 (300)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Life expectancy, free of chronic condition-induced activity limitations among White and Black Americans, 2000-2006 [PDF]

Objective-Life expectancy without activity limitations or active life expectancy is one of the health expectancy measures that is used to summarize population health.

core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cardiovascular Health and Life Expectancy in Chronic Kidney Disease. [PDF]

JACC Asia
Liu P, Liu D, Lan Y, Zhang Q, Lu Q, An K, Wang J, Chen S, Wu S, Wang Y.   +9 more
europepmc   +1 more source

The crossover between life expectancies at birth and at age one: The imbalance in the life table [PDF]

The single most used demographic measure to describe population health is life expectancy at birth, but life expectancies at ages other than zero are also used in the study of human longevity.
Stan Becker, Vladimir Canudas-Romo
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Changes in life expectancy due to trends in cancer mortality rates, Spain 1980 - 2024. [PDF]

Front Oncol
Llorca J, Gómez-Acebo I, Alonso-Molero J, Valero-Domínguez S, Dierssen-Sotos T.   +4 more
europepmc   +1 more source

A Dynamic Extension of the Period Life Table [PDF]

The standard period life table is based entirely on the death probabilities of the given period. Popular (not expert) usage of life expectancies from a period table typically ignores the fact that the expectancies make no allowance for future declines in
Byron G Spencer, Frank T Denton
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A multi-stage stacking framework for accurate and interpretable life expectancy modeling. [PDF]

PLoS One
Chinthaginjala R, Tera SP, Natha P, Srinivasulu A, Al-Turjman F, Mohammad F.   +5 more
europepmc   +1 more source