Results 91 to 100 of about 15,495,313 (386)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

A late surviving Pliocene seal from high latitudes of the North Atlantic realm: the latest monachine seal on the southern margin of the North Sea [PDF]

open access: yesPeerJ, 2018
Background The family of true seals, the Phocidae, is subdivided into two subfamilies: the southern Monachinae, and the northern Phocinae, following the subfamilies’ current distribution: extant Monachinae are largely restricted to the (sub-)Antarctic ...
Leonard Dewaele   +2 more
doaj   +2 more sources

Life history of Monocystis parasites and genetic diversity of their hosts, the invasive Amynthas earthworms [PDF]

open access: yes, 2016
Monocystis is a parasites in the phylum Apicomplexa that infects nearly 100% of earthworms; however, the parasites have low survivorship, low production of transmissible gametocysts, and seemingly lack schizogony.
Keller, Erin L.
core   +1 more source

Book Review: \u3cem\u3eModern Hindu Personalism: The History, Life and Thought of Bhaktisiddhānta Sarasvatī\u3c/em\u3e [PDF]

open access: yes, 2016
Book Review of Modern Hindu Personalism: The History, Life and Thought of Bhaktisiddhānta Sarasvatī. Ferdinando Sardella.
McLaughlin, Michael
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

The Challenge of Parenting Girls in Neighborhoods of Different Perceived Quality

open access: yesSocieties, 2014
It is well-known that disadvantaged neighborhoods, as officially identified through census data, harbor higher numbers of delinquent individuals than advantaged neighborhoods.
Lia Ahonen   +3 more
doaj   +1 more source

Speaking of memory... [PDF]

open access: yes, 2010
Article explores how memory is created in narrative focusing on architects' life history ...
Sandino, Linda
core  

An amniote life-history database to perform comparative analyses with birds, mammals, and reptiles

open access: yes, 2015
Studying life-history traits within and across taxonomic classifications has revealed many interesting and important patterns, but this approach to life history requires access to large compilations of data containing many different life-history ...
Nathan P. Myhrvold   +5 more
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

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