Results 71 to 80 of about 2,069,818 (312)

Pooled Energy Budget and Human Life History [PDF]

open access: yes, 2009
Human life history contains a series of paradoxes not easily explained by classical life history theory. While overall reproductive output is higher than in related primates, juvenile growth is slower and age-specific reproductive rates decline faster ...
Reiches, Meredith W.   +11 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Life on the Ohio River History Musuem

open access: yes, 2000
Life on the Ohio River History Museum, located in Vevay, Indiana, Switzerland County, features a rare and diverse collection of documents and artifacts depicting life and work along the Ohio River.
Life on the Ohio River History Musuem
core  

Life-history responses, transmission dynamics and epidemiology in a terrestrial gastropod infected with parasitic mites [PDF]

open access: yes, 2010
Parasites are known to influence the life-history of their hosts. A parasite-induced reduction in host fecundity and survival may lead to a reduced rate of increase in the host population.
Schüpbach, Hans Ulrich
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Habitat-Selecting Life History

open access: yesFishes
Adaptive life histories emerge through their environmentally dependent effects on fitness. Those effects are consequences of habitat quality and the density-dependent decisions that organisms make on habitat choice. Density dependence for ideal organisms
Douglas W. Morris, Per Lundberg
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Instructions: General Suggestions to Author (History of American Life)

open access: yes, 1923
Instructions for the authors for Arthur M. Schlesinger's series History of American Life. Typed pages.
Schlesinger, Arthur M.
core  

The Challenge of Parenting Girls in Neighborhoods of Different Perceived Quality

open access: yesSocieties, 2014
It is well-known that disadvantaged neighborhoods, as officially identified through census data, harbor higher numbers of delinquent individuals than advantaged neighborhoods.
Lia Ahonen   +3 more
doaj   +1 more source

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