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Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

High-accuracy fatigue life prediction and early fracture warning for ferromagnetic metals via spin correlation amplification. [PDF]

open access: yesNat Commun
Zhang B   +11 more
europepmc   +1 more source
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Predictive Sequential Life Testing

Biometrika, 1978
Sequential tests that are based on some unobservable parameter have been well investigated using both classical and Bayesian approaches; see, for example, Wald (1947) and Barnett (1972). In this paper we use the Bayesian predictive density function to constuct a sequential test that is based on some statistic of a future sample, and investigate the ...
Bancroft, G. A., Dunsmore, I. R.
openaire   +2 more sources

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