Results 41 to 50 of about 679,610 (316)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Telomere length in early life predicts lifespan [PDF]

Proceedings of the National Academy of Sciences, 2012
The attrition of telomeres, the ends of eukaryote chromosomes, is thought to play an important role in cell deterioration with advancing age. The observed variation in telomere length among individuals of the same age is therefore thought to be related to variation in potential longevity.
Heidinger, Britt J., Blount, Jonathan D., Boner, Winnie, Griffiths, Kate, Metcalfe, Neil B., Monaghan, Pat   +11 more
openaire   +2 more sources

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Resilience index improves prediction of 1-year decreased quality of life in breast cancer

, 2022
Background Resilience is important in cancer survivorship and has great potential to predict long-term quality of life (QoL) in breast cancer. The study was designed to develop a new prediction model to estimate pretest probability (PTP) of 1-year ...
Zhe SUN, Molasiotis, A., Yu, Y.L., Guang Yun HU, Zeng Jie YE, Knobf, M. T., Ye, Z.J., Mu Zi LIANG, Peng CHEN, M. Tish Knobf, Alex Molassiotis, Chen, P., Sun, Z., Yuan Liang YU, Tang, Y., Liang, M. Z., Ying TANG, Hu, G. Y.   +17 more
core   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Performance based creep life estimation for gas turbines application [PDF]

, 2011
Accurate and reliable component life prediction is crucial to ensure both the safety and economics of gas turbine operations. In the pursuit of improved accuracy and reliability, current model-based creep life estimation methods have become more and ...
Abdul Ghafir, Mohammad Fahmi Bin
core  

Comparative Analysis of Battery Cycle Life Early Prediction Using Machine Learning Pipeline [Elektronisk resurs]

, 2023
Lithium-Ion battery system is one of the most critical but expensive components for both electric vehicles and stationary energy storage applications. In this regard, accurate and reliable early prediction of battery lifetime is important for optimizing ...
Gros, Sebastien,, Wik, Torsten,, Altaf, Faisal,, Zhang, Huang,   +3 more
core   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Low Cycle Fatigue Behaviors of Single Crystal Nickel-based Superalloy at Temperatures of 600~760 ℃

Journal of Aeronautical Materials, 2018
Low cycle fatigue (LCF) tests were conducted on a single crystal nickel-based superalloy DD6 with crystallographic orientations [001] at different elevated temperatures. The typical temperatures selected are 600 ℃, 650 ℃, 700 ℃ and 760 ℃, which represent
ZHANG Zhihua, YU Huichen, LI Ying, DONG Chengli   +3 more
doaj   +1 more source