Results 81 to 90 of about 2,032,204 (309)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

FE implementation of damage-coupled inelastic constitutive equation for P91 steel

Mechanical Engineering Journal
The objective of this study is to numerically evaluate the cyclic softening behavior and creep-fatigue damage of P91 steel. To achieve this, a damage-coupled inelastic constitutive equation is formulated by coupling the Chaboche-type viscoplastic ...
Masayuki ARAI, Akihiro MOTOKI
doaj   +1 more source

Life prediction and constitutive behavior [PDF]

One of the primary drivers that prompted the initiation of the hot section technology (HOST) program was the recognized need for improved cyclic durability of costly hot section components.
Halford, G. R.
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Research Progress and Prospect on Fatigue Life and Failure Mechanism of Drill Pipe

Shiyou jixie
With oil and gas drilling is developing towards the directions of ultra⁃deep， large displacement， high temperature， high pressure and high corrosion environments. The issue of drill pipe fatigue failure has become increasingly prominent.
Peng Xianbo, Dou Liangbin, Li Wei, Chen Chen, Yang Xiaoyong   +4 more
doaj  

EMUs Electrical Connector Life Prediction Based on Accelerated Degradation Data

机车电传动, 2019
The electrical connectors of EMUs play a very important role in train operation. In order to improve the efficiency and accuracy of life prediction of electrial connector products, the connector accelerated test was designed and implemented, and the ...
Jie MA, Lide WANG, Chuan YUE, Ping SHEN, Ji QIU   +4 more
doaj  

Three dimensional thrust chamber life prediction [PDF]

A study was performed to analytically determine the cyclic thermomechanical behavior and fatigue life of three configurations of a Plug Nozzle Thrust Chamber. This thrust chamber is a test model which represents the current trend in nozzle design calling
Armstrong, W. H., Brogren, E. W.
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source