Results 51 to 60 of about 7,761,502 (287)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Fiscal Policies, Decentralization, and Life Satisfaction [PDF]

open access: yes, 2021
This paper studies the relationship between wellbeing and governments’ fiscal policies across the world, including government decentralization, over the period between 1999 and 2018.
Ortega Gil, Manuela
core  

The structure of psychological life satisfaction: insights from farmers and a general community sample in Australia

open access: yesBMC Public Health, 2012
Background Psychological life satisfaction is a robust predictor of wellbeing. Public health measures to improve wellbeing would benefit from an understanding of how overall life satisfaction varies as a function of satisfaction with multiple life ...
OBrien Léan V   +2 more
doaj   +1 more source

Determinants of Happiness and Life Satisfaction: The Life Satisfaction Survey of the Turkish Statistical Institute

open access: yesSosyal Siyaset Konferansları Dergisi, 2021
The main focus area of economic science is the welfare and well-being of individuals in society. This requires measuring factors and monitoring their progress over time.
Sema Ulutürk Akman
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Studying the Relation between Life Orientering and Advancement Goals with Students’ Life Satisfaction [PDF]

open access: yesروان‌شناسی تربیتی, 2015
One of the most important effects in life satisfaction is goal and positive orientation to life. The purpose of this research was to study the relation between life Orientation and advancement goals with students’ life satisfaction.
Hassan mahmoudian   +4 more
doaj  

Life Satisfaction and Work-Related Satisfaction among Anesthesiologists in Poland

open access: yesThe Scientific World Journal, 2014
The aim of the study was to assess the level of life and job satisfaction of Polish anesthesiologists and to explore the impact of extrinsic-hygiene and intrinsic-motivating determinants. Materials and Methods.
Ewelina Gaszynska   +4 more
doaj   +1 more source

Do wage and wage satisfaction compensate for the effects of a dissatisfying job on life satisfaction?

open access: yesSA Journal of Industrial Psychology, 2019
Orientation: Research regarding subjective well-being (including life satisfaction and domain-specific satisfaction) is necessary, given the effects thereof on health, work performance, social relationships and ethical behaviour of employees.
Jacob A. de Coning   +2 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

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