Results 181 to 190 of about 8,033,101 (355)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Editorial: Micro/nano devices and technologies for neural science and medical applications

open access: yesFrontiers in Bioengineering and Biotechnology
Juntao Liu   +4 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Highlighting Counterstereotypical Scientists in Undergraduate Life Science Courses. [PDF]

open access: yesCBE Life Sci Educ
Costello RA   +27 more
europepmc   +1 more source

Integrating bioinformatic strategies in spatial life science research. [PDF]

open access: yesBrief Bioinform, 2022
Hao Y   +11 more
europepmc   +1 more source

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