Results 171 to 180 of about 8,218,819 (301)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Flexible competency framework: A tool for optimizing life science training. [PDF]

PLoS Biol
Li X, Patrnogić J, Van Vactor D.
europepmc   +1 more source

Context-based refinement of mappings in evolving life science ontologies. [PDF]

J Biomed Semantics, 2023
Yamamoto VE, Destro JM, Dos Reis JC.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Case study: creating an 'AI for Academic Writing Skills' induction session for postgraduate life science courses. [PDF]

Emerg Top Life Sci
Carter J, Ferrey A, Lam H, Webb-Davies K, Young D, Zonta B, O' Rourke D.   +6 more
europepmc   +1 more source

Emerging Field-Effect Transistor Biosensors for Life Science Applications. [PDF]

Bioengineering (Basel), 2023
Panahi A, Ghafar-Zadeh E.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Highlighting Counterstereotypical Scientists in Undergraduate Life Science Courses. [PDF]

CBE Life Sci Educ
Costello RA, Ewell SN, Adams PE, Aranda ML, Curry A, De Jesus MM, Dunk RDP, García-Ojeda ME, Gutzler SJ, Habersham LRA, Kjelvik MK, Mateen M, Metzger KJ, Mulligan KX, Owens MT, Pigg RM, Quillin K, Rice MM, Sovi S, Schultheis EH, Schultz J, Theobald EJ, Tracey E, Tripp B, Yang S, Zemenick A, Ballen CJ, Ovid D.   +27 more
europepmc   +1 more source

Integrating supercomputing and artificial intelligence for life science. [PDF]

Patterns (N Y), 2022
Rao J, Zheng S, Yang Y.
europepmc   +1 more source

Science and the Quality of Life [PDF]

Science, 1974
openaire   +2 more sources