Results 181 to 190 of about 8,218,819 (301)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Turning data into insights in Jub, an extensible generic big data platform for life science and healthcare applications. [PDF]

Sci Rep
Castillo-Barrios I, Crespo-Sanchez M, Reyes-Anastacio HG, Gonzalez-Compean JL, Lopez-Arevalo I, Barron-Lugo JA, Morin-Garcia JC, Leal YA, Calderon-Hernandez J, Aguirre-Meneses H, Núñez-Gaona MA.   +10 more
europepmc   +1 more source

The effectiveness of Japanese public funding to generate emerging topics in life science and medicine. [PDF]

PLoS One, 2023
Ohniwa RL, Takeyasu K, Hibino A.
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A Scoping Review of Published Lesson Plans Showcases Two Decades of Change in Undergraduate Life Science Education Resources. [PDF]

CBE Life Sci Educ
Treibergs KA, Stetzer MR, Olson AN, Schmid K, Adjei-Opong T, Onimode R, Noyes K, Eldermire ERB, Couch BA, Smith MK.   +9 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Investigating cognitive-enhancing supplement use among students at a Dutch life science university. [PDF]

PLoS One
Escano E, Sezer N, Pustjens AM.
europepmc   +1 more source

Integrating bioinformatic strategies in spatial life science research. [PDF]

Brief Bioinform, 2022
Hao Y, Lu L, Liu A, Lin X, Xiao L, Kong X, Li K, Liang F, Xiong J, Qu L, Li Y, Li J.   +11 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Brilliant life in science

Інтродукція Рослин, 2006
T.M. Cherevchenko, S.V. Klimenko, N.M. Shyian, O.M. Tsarenko, P.E. Bulakh, O.V. Bulakh, L.I. Buyun, L.A. Kovalska, V.S. Vahrushkin   +8 more
doaj   +1 more source