Results 91 to 100 of about 6,108,300 (348)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

open access: yesFEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez   +3 more
wiley   +1 more source

The Sustainable Development of Zootechnical Sciences in the Context of Life Sciences and the Perspectives of Zootechnical Engineers in the Innovative Concept of Eco-Bio-Economic Engineering

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
Zootechnical sciences represent a well defined concept since the notion of “Zootechnics” has been in use (in the second part of the 19th c.) and they continued to develop throughout the 20th century and they have acquired new insights in the early 21st c.
Alexandru T. Bogdan   +2 more
doaj  

Designing for the Life Sciences: The Epistemology of Elite Life Science Real Estate

open access: yesTecnoscienza, 2015
In this article trends in the design of iconic elite life science buildings is discussed. Four main elite life science buildings of the new century are considered. The buildings reflect things going on in and around elite contemporary life science today,
Charis M. Thompson
doaj   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

open access: yesFEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring   +6 more
wiley   +1 more source

The Origin of Life in the Universe [PDF]

open access: yesProc.of AP Akademi of Sciences Vol.6,No.2, 2002(Special Issue on Astrnomy), 2002
Terrestrial and extraterrestrial theories of the origin of life are discussed in the light of latest observations. The available data suggest a dual mode of origin, some of the ingredients, including possibly sugars, were brought to earth from outer space, which combined with other ingredients, such as proteins, already available on the earth leading ...
arxiv  

Microfluidics and the Life Sciences

open access: yesScience Progress, 2012
The field of microfluidics, often also referred to as “Lab-on-a-Chip” has made significant progress in the last 15 years and is an essential tool in the development of new products and protocols in the life sciences. This article provides a broad overview on the developments on the academic as well as the commercial side.
Claudia Gärtner, Holger Becker
openaire   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Life and work of the mathemagician Srinivasa Ramanujan [PDF]

open access: yesarXiv, 2000
The Life of Srinivasa Ramanujan (1887 - 1920), the renowned Indian Mathematician, is presented, in this the first of a series of lectures, delivered at the Indian Institute for Advanced Study, Shimla.
arxiv  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

open access: yesFEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek   +15 more
wiley   +1 more source

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