Results 111 to 120 of about 2,956,560 (314)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Scientometric Analysis: An Emerging Tool in Veterinary and Animal Scientific Research
AnimalsThe present study is an evaluation of published papers in the field of scientometrics–bibliometrics in veterinary or animal studies. The objective was the quantitative evaluation of the scientific content and the bibliometric details of papers that had ...
Georgia A. Vaitsi +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Exploring Life Sciences Pre-Service Teachers' Competences in Education for Sustainable Development
Araştırma Temelli Etkinlik DergisiThis paper explores the competencies of Life Sciences pre-service teachers in Education for Sustainable Development (ESD), following UNESCO's 2030 call to address global sustainability challenges.
Gaseitsekgosi Dimakatso, Glen Legodu
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Artificial Intelligence in Medicine: Preparing for the Confirmed Inevitable. Theoretical and Methodological Considerations [PDF]
Journal of Systemics, Cybernetics and Informatics, 2019 The AI in Medicine project began with a simple yet complex and multilevel question. In late 2017, prompted by direct experience of researching human-machine interchanges, we asked whether the traditional principles of interaction between a physician and ...
Andrey V. Rezaev, Piotr K. Yablonskiy
doaj
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Book of Abstracts. 14th International Conference on Biosystems Engineering 2024, May 8–10, 2024 Tartu, Estonia.
Estonian University of Life Sciences
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Growing Molecular Plant Sciences
, 2014 The VT Molecular Plant Sciences Magazine features the work of scientists and students in the department who use molecular approaches to unravel the mysteries of ...
Molecular Plant Sciences +1 more
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