Results 151 to 160 of about 2,956,560 (314)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Forum: Qualitative Social Research, 2014 In the wake of contemporary new public management, the temporalities of academic work have undergone significant transformations. One key feature of these changes is a perceived acceleration of working pace.
Ruth Müller
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
This conference is jointly organised by the ERA Chair COMBIVET and OHBoost Twinning Project of the Estonian University of Life Sciences in partnership with the University of Tartu (UT), University of Helsinki (UH) the University of Milan (UniMi) and ...
Estonian University of Life Sciences
core
Agroforum Mare Balticum 2016 : conference proceedings : 19th - 21st April 2016, Tartu, Estonia
, 2016 Conference proceedingsThe annual international agricultural forum Agroforum Mare Balticum will be held, already for the fourth time now, in Tartu, Estonia.
Estonian University of Life Sciences
core
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Nonlinear Dynamics, Psychology, and Life Sciences
Nonlinear Dynamics, Psychology, and Life Sciences publishes articles that augment the fundamental ways we understand, describe, model and predict nonlinear phenomena in psychology and the life and social sciences.
DIECI, ROBERTO
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source