Results 191 to 200 of about 30,042,162 (342)

Artificial Intelligence for Discovery in Life Sciences. [PDF]

Bioconjug Chem
Chanda S, Rizzoli SO, Shaib AH.
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

bio.tools: an expanded web service for research software in the life sciences. [PDF]

Nucleic Acids Res
Mendes AIS, Ienasescu H, Andersen CAT, Calhoun E, Chmura PJ, Collier K, Goga I, Gustafsson OJR, Kalaš M, Kierkegaard M, Nielsen NK, Jaaniso E, Jensen JRB, Ludl AA, Ménager H, Palmblad M, Magyar Z, Raček T, Rošinec A, Rusz F, Steeghs-Turchina M, Szmigiel A, Svobodová R, Schwämmle V.   +23 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Neonataalperioodi mõju piimalehmade tervisele ja toodangule

A Thesis for applying for the degree of Doctor of Philosophy in Veterinary Science.Väitekiri filosoofiadoktori kraadi taotlemiseks loomaarstiteaduse erialal.ABSTRACT.
Loch, Marina
core   +1 more source

Cultivating Enduring Changes in Assessment Through a Life Sciences Community of Practice. [PDF]

Biochem Mol Biol Educ
Tyler L, Kennelly PJ, Engelman S, Loertscher J, Bobenko JC, Wei Y, Block KF, McCulloch KM, Trivedi VD, Lane KT, Linenberger Cortes KJ, Moore VDG, Dries DR.   +12 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Kahjurite jätkusuutlikud tõrjestrateegiad rapsi integreeritud taimekaitses

A Thesis for applying for the degree of Doctor of Philosophy in Agricultural Sciences.Väitekiri filosoofiadoktorikraaditaotlemiseks põllumajanduse erialal.ABSTRACT.
Vilumets, Silva
core   +1 more source

Pithos - a scalable and secure data container for FAIR-compliant research data management in life sciences. [PDF]

J Integr Bioinform
Schlegel J, Beyvers S, Hansen M, Brehm L, Goesmann A, Förster F.   +5 more
europepmc   +1 more source