Results 211 to 220 of about 2,956,560 (314)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Enabling global image data sharing in the life sciences. [PDF]

Nat Methods
Bajcsy P, Bhattiprolu S, Börner K, Cimini BA, Collinson L, Ellenberg J, Fiolka R, Giger M, Goscinski W, Hartley M, Hotaling N, Horwitz R, Jug F, Kemmer I, Kreshuk A, Lundberg E, Mathur A, Narayan K, Onami S, Plant AL, Prior F, Swedlow JR, Taylor A, Keppler A.   +23 more
europepmc   +1 more source

Henri Poincaré's life, science, and life in science

, 2017
Essay review of Jeremy Gray, Henri Poincaré: A Scientific Biography, Princeton University Press, 2013.
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Molecular life sciences in the era of the Fourth Industrial Revolution: sequencing, multi-omics and artificial intelligence. [PDF]

Emerg Top Life Sci
Keenan L, Lorna Younger R, Race PR, Bawn M.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Helping Students See and Identify Purpose and Relevance in Life Sciences Courses. [PDF]

CBE Life Sci Educ
Thoman DB, Sutter CC, Smith JL, Hulleman CS.   +3 more
europepmc   +1 more source

December-science and . . . life [PDF]

Journal of Experimental Botany, 2003
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Attitudes of medical and life sciences university students and postdoctoral fellows toward AI chatbots in education: an international cross-sectional survey. [PDF]

Sci Rep
Ng JY, Shah AQ, Roni E, Asna M, Brar J, Kathirkamanathan S, Li W, Lokker C, Iorio A, Haynes RB, Moher D.   +10 more
europepmc   +1 more source