Results 61 to 70 of about 39,862 (302)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Spatio-temporal dynamic evolution characteristics and driving mechanism analysis of urban pseudo human settlements

open access: yesFrontiers in Earth Science
Pseudo human settlements in the information age is an important part of human settlements geography, which has a comprehensive and profound impact on urban production, life and ecology in China and even the world, but the existing research on pseudo ...
Hang Li   +18 more
doaj   +1 more source

New forms of dwelling – sustainable urban communities [PDF]

open access: yesUrbani Izziv, 2000
Various new forms of settlements composed of sustainable communities are emerging all around the World as answers to the urban crises in great cities. These settlements differ, especially when comparing the countries where they appear.
Mojca Šašek Divjak
doaj  

Experience of comprehensive field studies with the use of UAVs in solving tasks for the assessment of flood zones of settlements (on the example of the Pechora River)

open access: yesВодное хозяйство России: проблемы, технологии, управление, 2023
Most of the human settlements in the lower reaches of the Pechora River are subject to periodic flooding, and as a result, the occurrence of socio-economic risks for the life of the population of riverside territories.
Anton I. Luchnikov   +2 more
doaj   +1 more source

Development of Social Life Circumstance of Urban Fringe Settlements in China Central Region

open access: yes, 2013
Along with the triumphant advance of urbanization in central China central region and disorderly unwinding of cities, urban fringe settlements are incorporated into urban expansion territory, so that villagers became landless peasants.
YE, Yun, LIU, Xingyu
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Amish Settlements across America: 2013

open access: yesThe Journal of Amish and Plain Anabaptist Studies, 2013
This short research report is based upon previous editions of “Amish Settlements across North America,” which was published periodically in Family Life.
Joseph Donnermeyer, David Luthy
doaj  

Women's access to land and housing post-1994 in the informal settlements at Ficksburg in the Free State South Africa

open access: yes, 2010
This dissertation investigated the constraints that inhibit women from getting access to formal housing and land in Ficksburg in the Free State province of South Africa.
Kane, Mookho
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Green infrastructure in relation to informal urban settlements

open access: yesJournal of Architecture and Urbanism, 2017
Green infrastructure plays a critical role in environmentally sustainable urbanization in developing countries. Based on a review of academic outputs, this paper explores green infrastructure in the context of informal urban settlements.
Olumuyiwa Bayode Adegun
doaj   +1 more source

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