Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Impact of a health coaching intervention on anthropometric indicators, physical activity, and life style of infertile women with polycystic ovary syndrome: A quasi-experimental study. [PDF]
BMC Res NotesDelavar MA +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders. [PDF]
Exp Mol MedRamachandran R, Manan A, Kim J, Choi S.
europepmc +1 more source
A community-level educational intervention trail to study the impact of life style modification in control of hypertension and diabetes- A non-randomized trial (Before and after intervention study without control). [PDF]
J Family Med Prim Care, 2022 Kundapur R +5 more
europepmc +1 more source
Relationship Between Life Style and Marital Satisfaction
, 2015 The aim of the present study was to determine the relationship between life style and marital satisfaction in married students of all universities in Isfahan. The method of research was descriptive correlation. Statistical population consisted of married
سمیه پورمیدانی +2 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Analysis of the mediating role of life style in the relationship between health literacy and self-rated health employing structural equation modeling. [PDF]
Sci RepBagherinia M +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source