Results 181 to 190 of about 303,873 (302)

NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders. [PDF]

Exp Mol Med
Ramachandran R, Manan A, Kim J, Choi S.
europepmc   +1 more source

A community-level educational intervention trail to study the impact of life style modification in control of hypertension and diabetes- A non-randomized trial (Before and after intervention study without control). [PDF]

J Family Med Prim Care, 2022
Kundapur R, Modi B, Mary L, Manjula R, Santhosh P, Saxena D.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Analysis of the mediating role of life style in the relationship between health literacy and self-rated health employing structural equation modeling. [PDF]

Sci Rep
Bagherinia M, Rezaeian S, Shakiba E, Maleki R, Mohammad Karimi Mazhin A, Darvishigilan H, Janatolmakan M, Karami B.   +7 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Modifiable life style factors and male reproductive health: a cross-sectional study in IVF clinic attendees in Ghana. [PDF]

Front Reprod Health
Amoah BY, Yao Bayamina S, Gborsong C, Owusu H, Asare GA, Yeboah EK, Ablakwa J, Hammond G.   +7 more
europepmc   +1 more source

Epidemiological, life style, and occupational factors associated with lower limb varicose veins: a case control study. [PDF]

J Egypt Public Health Assoc, 2021
Elamrawy S, Darwish I, Moustafa S, Elshaer N, Ahmed N.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

[Life style].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1993
  +5 more sources

Life-style and metabolic factors do not affect risk for glioma: a prospective population-based study (The Cohort of Norway). [PDF]

Front Oncol
Gheorghiu A, Brunborg C, Johannesen TB, Helseth E, Zwart JA, Wiedmann MKH.   +5 more
europepmc   +1 more source