Results 91 to 100 of about 1,604,294 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diverse Redundant Systems for Reliable Space Life Support

, 2015
Bellevue, WashingtonHarry W. Jones, NASA Ames Research Center, USAHarry W. Jones, NASA Ames Research Center, USAThe 45th International Conference on Environmental Systems was held in Bellevue, Washington, USA on 12 July 2015 through 16 July 2015.Reliable
Jones, Harry W.
core  

Time-course transcriptome data of silk glands in day 0–7 last-instar larvae of Bombyx mori (w1 pnd strain)

Scientific Data
Time-course transcriptome expression data were constructed for four parts of the silk gland (anterior, middle, and posterior parts of the middle silk gland, along with the posterior silk gland) in the domestic silkworm, Bombyx mori, from days 0 to 7 of ...
Yudai Masuoka, Akiya Jouraku, Takuya Tsubota, Hiromasa Ono, Hirokazu Chiba, Hideki Sezutsu, Hidemasa Bono, Kakeru Yokoi   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Life support systems integration

, 1967
Subsystem, system, and total spacecraft integration studies for regenerative life support systems and environmental ...
Hypes, W. D.
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Life Support Goals Including High Closure and Low Mass Should Be Reconsidered Using Systems Analysis

, 2017
Harry Jones, NASA Ames Research Center (ARC), USAICES501: Life Support Systems Engineering and AnalysisThe 47th International Conference on Environmental Systems was held in South Carolina, USA on 16 July 2017 through 20 July 2017Recycling space life ...
Jones, Harry
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Plant and microbial science and technology as cornerstones to Bioregenerative Life Support Systems in space. [PDF]

NPJ Microgravity, 2023
De Micco V, Amitrano C, Mastroleo F, Aronne G, Battistelli A, Carnero-Diaz E, De Pascale S, Detrell G, Dussap CG, Ganigué R, Jakobsen ØM, Poulet L, Van Houdt R, Verseux C, Vlaeminck SE, Willaert R, Leys N.   +16 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source