Results 41 to 50 of about 101,150 (170)

Shared Decision-making in Emergency Life-sustaining Treatment

Yixue yu zhexue
Shared decision-making (SDM) model has been widely recognized in the world, but its practice in China is still in the exploratory stage. SDM has a broad implementation prospect in emergency department, where patients with serious illness and their family
Jun WU, Shu LI
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Predictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study

Journal of Intensive Care
Background Clinical practice guidelines on limitation of life-sustaining treatments (LST) in the intensive care unit (ICU), in the form of withholding or withdrawal of LST, state that there is no ethical difference between the two.
Clare Fong, Wern Lunn Kueh, Sennen Jin Wen Lew, Benjamin Choon Heng Ho, Yu-Lin Wong, Yie Hui Lau, Yew Woon Chia, Hui Ling Tan, Ying Hao Christopher Seet, Wen Ting Siow, Graeme MacLaren, Rohit Agrawal, Tian Jin Lim, Shir Lynn Lim, Toon Wei Lim, Vui Kian Ho, Chai Rick Soh, Duu Wen Sewa, Chian Min Loo, Faheem Ahmed Khan, Chee Keat Tan, Roshni Sadashiv Gokhale, Chuin Siau, Noelle Louise Siew Hua Lim, Chik-Foo Yim, Jonathen Venkatachalam, Kumaresh Venkatesan, Naville Chi Hock Chia, Mei Fong Liew, Guihong Li, Li Li, Su Mon Myat, Zena Zena, Shuling Zhuo, Ling Ling Yueh, Caroline Shu Fang Tan, Jing Ma, Siew Lian Yeo, Yiong Huak Chan, Jason Phua, for SICM-NICER group   +40 more
doaj   +1 more source

End-of-life discussions reduce the utilization of life-sustaining treatments during the last three months of life in cancer patients

Scientific Reports, 2022
Studies to examine the impact of end-of-life (EOL) discussions on the utilization of life-sustaining treatments near death are limited and have inconsistent findings.
Shang-Yih Chan, Yun-Ju Lai, Yu-Yen Chen, Shuo-Ju Chiang, Yi-Fan Tsai, Li-Fei Hsu, Pei-Hung Chuang, Chu-Chieh Chen, Yung-Feng Yen   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A study of the documentation of withholding and withdrawing life‐sustaining therapies in a tertiary intensive care unit in Hong Kong

Hong Kong Journal of Emergency Medicine
Background In the Intensive Care Unit (ICU), recommended end‐of‐life (EOL) care practice encompasses do‐not‐attempt cardiopulmonary resuscitation (DNACPR), withholding (WH), and withdrawing (WD) life‐sustaining treatment (LST).
Duncan Ka‐Hin Lam, Wai‐Tat Wong, Gavin Matthew Joynt   +2 more
doaj   +1 more source

The Problems With Physician Orders for Life-Sustaining Treatment [PDF]

JAMA, 2016
In 1991, physicians in Oregon developed the Physician Orders for Life-Sustaining Treatment (POLST) program to address a specific and substantive problem: due to societal defaults toward cardiopulmonary resuscitation (CPR) and life support absent orders to the contrary, many seriously ill patients receive unwanted resuscitation and hospitalization.
Kendra A, Moore, Emily B, Rubin, Scott D, Halpern   +2 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source