Results 81 to 90 of about 467,188 (304)

Preferences and Attitudes Towards Life-Sustaining Treatments of Older Chinese Patients and Their Family Caregivers

Clinical Interventions in Aging, 2023
Tingting Zhu,1,2 Dongling Liu,1 Agnes van der Heide,2 Ida J Korfage,2 Judith AC Rietjens2 1Department of Nursing and Health, Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Public Health, Erasmus MC, University Medical Center ...
Zhu T, Liu D, van der Heide A, Korfage IJ, Rietjens JA   +4 more
doaj  

Autonomy versus futility? Barriers to good clinical practice in end-of-life care: a Queensland case [PDF]

, 2012
Findings from a Queensland coronial inquest highlight the complex clinical, ethical and legal issues that arise in end-of-life care when clinicians and family members disagree about a diagnosis of clinical futility.
Lawrence, Sean, Milligan, Eleanor, Parker, Malcolm, White, Ben, Willmott, Lindy, Winch, Sarah   +5 more
core   +2 more sources

Withdrawal of life sustaining treatment

BMJ, 2002
Ms B, as she was called in court and in the media, was a 43 year old professional woman who in 1999 had a haemorrhage in a cavernous haemangioma in her upper spinal cord. After an almost complete recovery she had a re-bleed in February 2001, which rendered her quadriplegic and dependent on artificial ventilation. Specialists who reviewed her all agreed
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Process of life-sustaining treatment in general hospital: withholding and withdrawing

Revista de Bioética y Derecho, 2011
Introducción: La limitación del esfuerzo terapéutico (LET) es una práctica frecuente en los Servicios de Medicina Intensiva (SMI) que asocia a una mortalidad elevada.
Lorenzo Socias Crespí, Rosa Poyo-Guerrero Lahoz   +1 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Próba oceny sytuacji granicznych związanych z chorobą i umieraniem [DEATH AND DYING – BO RDERLINE CASES] [PDF]

Analiza i Egzystencja, 2013
The aim of this article is an attempt to evaluate the following issues related to thelast stage of illness and death: discontinue of artificial nutrition and hydration, discontinueor refrain from life-saving therapy or palliative sedation.Mentioned cases
Bogna Wach
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Advance Directives Under State Law and Judicial Decisions (Medical Decision-Making and the ‛Right to Die’ After Cruzan) [PDF]

, 1991
In the decision of the United States Supreme Court in Cruzan v. Director, Missouri Department of Health on June 25, 1990, a majority of the Court announced that it will leave to the states the question of what legal requirements may be imposed on ...
Areen, Judith C.
core   +1 more source