Results 41 to 50 of about 59,084 (261)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Adaptive WSN Scheduling for Lifetime Extension in Environmental Monitoring Applications

International Journal of Distributed Sensor Networks, 2011
Wireless sensor networks (WSNs) are often used for environmental monitoring applications in which nodes periodically measure environmental conditions and immediately send the measurements back to the sink for processing.
Jong Chern Lim, Chris Bleakley
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Joint Hybrid Transmission and Adaptive Routing for Lifetime Extension of WSNs

IEEE Access, 2018
In this paper, two hybrid multi-hop/single-hop opportunistic transmission strategies with adaptive routing are investigated for prolonging the network lifetime of wireless sensor networks (WSNs).
Chih-Min Yu, Meng-Lin Ku
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Lifetime-Based Discontinuous PWM for Cascaded H-Bridge Converters

IEEE Access
The cascaded H-bridge (CHB) is an attractive converter topology because it can provide voltage and power scalability. However, due to the difference in electrical and thermal characteristics of power devices, the CHB can be composed of cells with unequal
Anas Ibrahim, Mohamed Salem, Tomonobu Senjyu, Soichiro Ueda, Dahaman Ishak, Mahmood Swadi   +5 more
doaj   +1 more source

Solid state atomic processors for light [PDF]

Journal of the European Optical Society-Rapid Publications, 2008
This paper is devoted to optics in rare earth ion doped crystal at low temperature. In cryogenic conditions, interesting features come from absorption rather than from transparency.
Crozatier V., Gorju G., Lavielle V., Louchet A., Bretenaker F., Chanelière T., Goldfarb F., Lorgeré I., Le Gouët J.-L.   +8 more
doaj   +1 more source