Results 71 to 80 of about 1,970,939 (305)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

IGBT Module Lifetime Prediction Technology for Rail Transit

机车电传动, 2020
Rail transport IGBT module lifetime prediction technology has become research focuses due to China's rail transit vehicles entering the stage of overhaul, thus scientific module lifetime prediction method is the key to realize the IGBT converter life ...
Bin WANG, Lin CAO
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Integration of safety and sustainability criteria into early design stages of battery cell manufacturing machinery

Scientific Reports
There is currently a lack of guidance on implementing safety and sustainability at early design stages of battery cell manufacturing machinery. In this work, key European regulatory requirements for battery manufacturing and relevant Safe and Sustainable
Cristina Cerrillo, Gemma Mendoza, Guillermo Ormazabal, Vladimir Popok, Heiko Oetting, Benedikt Konersmann, Alessandro Tedeschi Gallo, Maeva Lavigne Philippot   +7 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

The user query based learning system for lifetime\ud prediction of metallic components [PDF]

, 2005
Real-World Data Mining Applications generally do not end up with\ud the creation of the models. The use of the model is the final purpose especially\ud in prediction tasks. The problem arises when the model is built based on much\ud more information than
Ge, Esther, Nayak, Richi, Li, Yuefeng, Xu, Yue   +3 more
core  

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Lifetime needle sharing: A predictive analysis

Journal of Substance Abuse Treatment, 1994
Through understanding predictors of needle sharing, it may be possible to design AIDS prevention interventions more effectively. Data were collected from a sample of 416 patients in two New York City methadone programs in 1990. Questions were asked about needle sharing and about a battery of predictors covering 11 psychosocial domains.
P H, Kleinman, R B, Millman, H, Robinson, M, Lesser, C, Hsu, P, Engelhart, I, Finkelstein   +6 more
openaire   +2 more sources

Lifetime prediction of composite materials

, 2021
Rear end structures are exposed to high vibration loads from rear mounted engines, therefore there is a need for structural (fuselage) fatigue studies. Provide a contribution to the mechanical characterization of aircraft composite rear end for rear mounted engine aircraft configurations (static, fatigue).
M. Kaminski, P. Paulmier
openaire   +1 more source