Results 51 to 60 of about 64,568 (266)

Climate change emergence over people’s lifetimes

Environmental Research: Climate, 2023
The emergence of climate change from background variability is a useful metric for identifying changes in local climate which may affect people and ecosystems.
Andrew D King, Hunter Douglas, Luke J Harrington, Ed Hawkins, Alexander R Borowiak   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Lifetime of a bouncing droplet [PDF]

Physical Review E, 2007
When a droplet is gently laid onto the surface of the same liquid, it stays at rest for a moment before coalescence. The coalescence can be delayed and sometimes inhibited by injecting fresh air under the droplet. This can happen when the surface of the bath oscillates vertically. In this case the droplet basically bounces on the interface.
Terwagne, Denis, Vandewalle, Nicolas, Dorbolo, Stéphane   +2 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Lifestyle for a lifetime [PDF]

Netherlands Heart Journal, 2015
Current guidelines for prevention and treatment of cardiovascular disease (CVD) emphasise the importance of a healthy lifestyle. There is now sufficient evidence that a multitude of lifestyle factors play an important role in the occurrence of CVD.
openaire   +2 more sources

A measurement of the KS lifetime [PDF]

Physics Letters B, 1987
12 pages, 1 figure, to be published in Physics Letters ...
LAI A, MARRAS D, BATLEY JR, BEVAN A, DOSANJH RS, GERSHON TJ, HAY B, KALMUS GE, LAZZERONI C, MUNDAY DJ, NEEDHAM MD, OLAIYA E, PARKER MA, WHITE TO, WOTTON SA, BARR G, BOCQUET G, CECCUCCI A, CUHADAR DONSZELMANN T, CUNDY D, D'AGOSTINI G, DOBLE N, FALALEEV V, FUNK W, GATIGNON L, GONIDEC A, GORINI B, GOVI G, GRAFSTROM P, KUBISCHTA W, LACOURT A, LENTI M, LUITZ S, MATHEYS JP, MIKULEC I, NORTON A, PALESTINI S, PANZER STEINDEL B, SCHINZEL D, TATISHVILI G, TAUREG H, VELASCO M, VOSSNACK O, WAHL H, CHESHKOV C, GAPONENKO A, HRISTOV P, KEKELIDZE V, MADIGOJINE D, MOLOKANOVA N, POTREBENIKOV Y, TKATCHEV A, ZINCHENKO A, KNOWLES I, MARTIN V, PARSONS H, SACCO R, WALKER A, CONTALBRIGO, Marco, DALPIAZ, Pietro, DUCLOS J, FRABETTI PL, GIANOLI, Alberto, MARTINI, Mara, PETRUCCI, Ferruccio Carlo, SAVRIE', Mauro, SCARPA, MARCELLA, BIZZETI A, CALVETTI M, COLLAZUOL G, GRAZIANI G, IACOPINI E, MARTELLI F, VELTRI M, BECKER HG, BLUMER H, COWARD D, EPPARD M, FOX H, HIRSTIUS A, HOLTZ K, KALTER A, KLEINKNECHT K, KOCH U, KOPKE L, DA SILVA PL, MAROUELLI P, PELLMANN I, PETERS A, SCHMIDT SA, SCHONHARTING V, SCHUE Y, WANKE R, WINHART A, WITTGEN M, CHOLLET JC, CREPE S, FAYARD L, ICONOMIDOU FAYARD L, OCARIZ J, UNAL G, WINGERTER SEEZ I, ANZIVINO G, CENCI P, IMBERGAMO E, LUBRANO P, MESTVIRISHVILI A, NAPPI A, PEPE M, PICCINI M, BERTANZA L, BIGI A, CALAFIURA P, CAROSI R, CASALI R, CERRI C, CIRILLI M, COSTANTINI F, FANTECHI R, GIUDICI S, MANNELLI I, PIERAZZINI G, SOZZI M, CHEZE JB, COGAN J, DE BEER M, DEBU P, DERUE F, FORMICA A, DE CASSAGNAC RG, MAZZUCATO E, PEYAUD B, TURLAY R, VALLAGE B, AUGUSTIN I, BENDER M, HOLDER M, MAIER A, ZIOLKOWSKI M, ARCIDIACONO R, BIINO C, CARTIGLIA N, GUIDA R, MARCHETTO F, MENICHETTI E, PASTRONE N, NASSALSKI J, RONDIO E, SZLEPER M, WISLICKI W, WRONKA S, DIBON H, FISCHER G, JEITLER M, MARKYTAN M, NEUHOFER G, PERNICKA M, TAUROK A, WIDHALM L, CA NA48 COLLABORATION   +159 more
openaire   +5 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source