Results 11 to 20 of about 1,156,300 (324)

Diagnostic and prognostic significance of cell death markers in patients with cirrhosis and acute decompensation

PLoS ONE, 2022
Background The transition from compensated to decompensated liver cirrhosis is a hallmark of disease progression, however, reliable predictors to assess the risk of decompensation in individual patients from routine diagnostics are lacking.
Philipp Stoffers, Sabrina Guckenbiehl, Martin Walter Welker, Stefan Zeuzem, Christian Markus Lange, Jonel Trebicka, Eva Herrmann, Christoph Welsch   +7 more
doaj   +2 more sources

Detection of the Atherosclerotic PCSK9 gene Inhibitors Through in silico Method to Improve Targeted Therapy

Biology, Medicine & Natural Product Chemistry, 2022
The PCSK9 is one of the most important marks for the evolution of therapeutic agents for atherosclerosis because its interaction with low-density lipoprotein receptors causes atherosclerosis.
Sabarinathan Sethuramalingam, Revathy Leena Ravi, Janet Rani Rajiah   +2 more
doaj   +1 more source

Ligand Binding Pathways and Conformational Transitions of the HIV Protease.

Biochemistry, 2018
It is important to determine the binding pathways and mechanisms of ligand molecules to target proteins to effectively design therapeutic drugs. Molecular dynamics (MD) is a promising computational tool that allows us to simulate protein-drug binding at ...
Yinglong Miao, Yu‐ming M. Huang, R. Walker, J. McCammon, Chia‐en A. Chang   +4 more
semanticscholar   +1 more source

Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding

Neural Regeneration Research, 2015
Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathfinding however, the interplay between these two factors is less studied.
Christopher M Madl, Sarah C Heilshorn
doaj   +1 more source

Larotrectinib in NTRK-Rearranged Solid TumorsPublished as part of the Biochemistry series "Biochemistry to Bedside".

Biochemistry, 2019
Members of the tropomyosin receptor tyrosine kinase (TRK) family include TRKA, TRKB, and TRKC (encoded by the genes NTRK1, NTRK2, and NTRK3, respectively).
F. H. Wilson, R. Herbst
semanticscholar   +1 more source

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

Frontiers in Neuroscience, 2020
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems.
Thao N. T. Ho, Nikita Abraham, Richard J. Lewis   +2 more
doaj   +1 more source

Bioinorganic Chemistry: Metal Ions in Biological Systems . Helmut Sigel, Ed. Dekker, New York. Vol. 1, Simple Complexes. 1974. xviii, 268 pp., illus. $21.75. Vol. 2, Mixed-Ligand Complexes. 1973. xvi, 294 pp., illus. $25.25. Vol. 3, High Molecular Complexes. 1974. xiv, 290 pp., illus. $22.75.; Inorganic Biochemistry . Gunther L Eichorn, Ed. Elsevier, New York, 1973. In two volumes. xxxviii, 1264 pp., illus. $110.

Science, 1974
L. H. Fignolet
openalex   +3 more sources

ABS–Scan: In silico alanine scanning mutagenesis for binding site residues in protein–ligand complex [v2; ref status: indexed, http://f1000r.es/4sf]

F1000Research, 2014
Most physiological processes in living systems are fundamentally regulated by protein–ligand interactions. Understanding the process of ligand recognition by proteins is a vital activity in molecular biology and biochemistry.
Praveen Anand, Deepesh Nagarajan, Sumanta Mukherjee, Nagasuma Chandra   +3 more
doaj   +1 more source

The five dimensions of receptor pharmacology exemplified by melatonin receptors: An opinion

Pharmacology Research & Perspectives, 2020
Receptology has been complicated with enhancements in our knowledge of G‐protein‐coupled‐receptor (GPCR) biochemistry. This complexity is exemplified by the pharmacology of melatonin receptors.
Jean A. Boutin, Céline Legros
doaj   +1 more source

The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

Nature Communications, 2018
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion ...
Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini, Peter Illes   +14 more
doaj   +1 more source