Results 11 to 20 of about 369,161 (297)
The variety of iron hydroxides that are formed in biological systems is considered in terms of prototype products which have been identified in synthetic media. Polynuclear hydroxy-oxo complexes with highly ordered domains are typically obtained in rather acid solutions of ferric ions whereas from strongly alkaline polyalcohol solutions very small ...
W. Schneider
+6 more sources
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems.
Thao N. T. Ho+2 more
doaj +1 more source
Plasmodium falciparum-related malaria represents a serious worldwide public health problem due to its high mortality rates. P. falciparum expresses rhoptry neck protein 4 (PfRON4) in merozoite and sporozoite rhoptries, it participates in tight junction ...
Fredy A. Pulido-Quevedo+5 more
doaj +1 more source
Most physiological processes in living systems are fundamentally regulated by protein–ligand interactions. Understanding the process of ligand recognition by proteins is a vital activity in molecular biology and biochemistry.
Praveen Anand+3 more
doaj +1 more source
Nitric oxide binds to the proximal heme coordination site of the ferrocytochrome c/cardiolipin complex: formation mechanism and dynamics. [PDF]
Mammalian mitochondrial cytochrome c interacts with cardiolipin to form a complex (cyt. c/CL) important in apoptosis. Here we show that this interaction leads to structural changes in ferrocytochrome c that leads to an open coordinate site on the central
Husu, I+4 more
core +4 more sources
The five dimensions of receptor pharmacology exemplified by melatonin receptors: An opinion
Receptology has been complicated with enhancements in our knowledge of G‐protein‐coupled‐receptor (GPCR) biochemistry. This complexity is exemplified by the pharmacology of melatonin receptors.
Jean A. Boutin, Céline Legros
doaj +1 more source
Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]
An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C.+3 more
core +2 more sources
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion ...
Gabriele Stephan+14 more
doaj +1 more source
Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site [PDF]
Background: Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P-2).
Ampe, Christophe+4 more
core +3 more sources