Results 11 to 20 of about 369,161 (297)

ChemInform Abstract: Iron Hydrolysis and the Biochemistry of Iron. The Interplay of Hydroxide and Biogenic Ligands

open access: closedChemInform, 1988
The variety of iron hydroxides that are formed in biological systems is considered in terms of prototype products which have been identified in synthetic media. Polynuclear hydroxy-oxo complexes with highly ordered domains are typically obtained in rather acid solutions of ferric ions whereas from strongly alkaline polyalcohol solutions very small ...
W. Schneider
  +6 more sources

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

open access: yesFrontiers in Neuroscience, 2020
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems.
Thao N. T. Ho   +2 more
doaj   +1 more source

Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane

open access: yesInternational Journal of Medical Microbiology, 2023
Plasmodium falciparum-related malaria represents a serious worldwide public health problem due to its high mortality rates. P. falciparum expresses rhoptry neck protein 4 (PfRON4) in merozoite and sporozoite rhoptries, it participates in tight junction ...
Fredy A. Pulido-Quevedo   +5 more
doaj   +1 more source

ABS–Scan: In silico alanine scanning mutagenesis for binding site residues in protein–ligand complex [v2; ref status: indexed, http://f1000r.es/4sf]

open access: yesF1000Research, 2014
Most physiological processes in living systems are fundamentally regulated by protein–ligand interactions. Understanding the process of ligand recognition by proteins is a vital activity in molecular biology and biochemistry.
Praveen Anand   +3 more
doaj   +1 more source

Nitric oxide binds to the proximal heme coordination site of the ferrocytochrome c/cardiolipin complex: formation mechanism and dynamics. [PDF]

open access: yes, 2010
Mammalian mitochondrial cytochrome c interacts with cardiolipin to form a complex (cyt. c/CL) important in apoptosis. Here we show that this interaction leads to structural changes in ferrocytochrome c that leads to an open coordinate site on the central
Husu, I   +4 more
core   +4 more sources

The five dimensions of receptor pharmacology exemplified by melatonin receptors: An opinion

open access: yesPharmacology Research & Perspectives, 2020
Receptology has been complicated with enhancements in our knowledge of G‐protein‐coupled‐receptor (GPCR) biochemistry. This complexity is exemplified by the pharmacology of melatonin receptors.
Jean A. Boutin, Céline Legros
doaj   +1 more source

Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]

open access: yes, 2013
An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C.   +3 more
core   +2 more sources

The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

open access: yesNature Communications, 2018
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion ...
Gabriele Stephan   +14 more
doaj   +1 more source

Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site [PDF]

open access: yes, 2002
Background: Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P-2).
Ampe, Christophe   +4 more
core   +3 more sources

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